Title
Lactic acid bacteria as antigen delivery vehicles for oral immunization purposes
Author
Pouwels, P.H.
Leer, R.J.
Shaw, M.
Heijne Den Bak-Glashouwer, M.J.
Tielen, F.D.
Smit, E.
Martinez, B.
Jore, J.
Conway, P.L.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1998
Abstract
In vaccination programmes in which large numbers of subjects are involved, the oral route of administration is more convenient as compared to the more frequently used parenteral route. This is particularly relevant when vaccines are to be applied in less industrialized countries. Lactic acid bacteria in general and strains of Lactobacillus in particular have a variety of properties which make them attractive candidates for oral vaccination purposes, e.g. GRAS status, adjuvant properties, mucosal adhesive properties and low intrinsic immunogenicity. An overview is given of current research aimed at unravelling the relationship between structure and properties of surface proteins of lactobacilli and in vivo colonization, in particular of species capable of adhering to epithelial cells in vitro. Secondly, the state of the art will be discussed with respect to antigen presentation by lactic acid bacteria. Finally, some preliminary immunological data of recombinant lactic acid bacterial strains expressing antigens from pathogens will be presented.
Subject
Nutrition
Adherence
Expression vector
Lactobacillus
Surface protein
Vaccine
Antigen
Bacterial protein
Membrane protein
Antigen presentation
Bacterial colonization
Bacterium adherence
Developing country
Drug delivery system
Epithelium cell
Expression vector
Immunization
Immunogenicity
Lactic acid bacterium
Lactobacillus
Protein structure
Review
Structure activity relation
Administration, Oral
Animals
Antigens
Bacterial Adhesion
Colony Count, Microbial
Drug Delivery Systems
Gene Expression Regulation, Bacterial
Genetic Engineering
Humans
Intestinal Mucosa
Lactobacillus
Lactococcus
Mice
Vaccines
Bacteria (microorganisms)
Lactobacillus
Posibacteria
To reference this document use:
http://resolver.tudelft.nl/uuid:9bdb32cc-8b00-49a5-a9c4-2f42a6bd1d18
DOI
https://doi.org/10.1016/s0168-1605(98)00048-8
TNO identifier
234470
ISSN
0168-1605
Source
International Journal of Food Microbiology, 41 (2), 155-167
Document type
article