Title
Central fat mass versus peripheral fat and lean mass: Opposite (adverse versus favorable) associations with arterial stiffness? The Amsterdam growth and health longitudinal study
Author
Ferreira, I.
Snijder, M.B.
Twisk, J.W.R.
van Mechelen, W.
Kemper, H.C.G.
Seidell, J.C.
Stehouwer, C.D.A.
TNO Arbeid
Publication year
2004
Abstract
Central and peripheral fatness seem to confer opposite (i.e. adverse vs. protective) effects on cardiovascular risk, but how this occurs is not clear. In addition, the role of peripheral lean mass needs to be elucidated. We therefore investigated, in 336 (175 women) 36-yr-old and apparently healthy adults, the relationship between trunk fat, peripheral fat, and peripheral lean mass on the one hand, and estimates of stiffness of three large arteries on the other. Body composition was assessed by dual-energy x-ray absorptiometry. Arterial properties were assessed by ultrasound imaging. We found that 1) trunk fat was positively (i.e. adversely) associated with stiffness of the carotid and femoral arteries, whereas peripheral fat was inversely (i.e. favorably) associated with stiffness of the brachial and the carotido-femoral segment; 2) peripheral lean mass was positively associated with arterial diameter and carotid compliance and inversely associated with stiffness of the carotido-femoral segment; and 3) after adjustment for the other body composition variables, the above-mentioned associations remained, but peripheral fat in addition became, if anything, favorably associated with stiffness of the femoral artery. We conclude that trunk fat is adversely associated with large artery stiffness, whereas some degree of protection is conferred by peripheral fat and lean mass.
Subject
artery diameter
atherosclerosis
body fat
brachial artery
cardiovascular risk
carotid artery
conference paper
controlled study
disease association
femoral artery
imaging system
lean body weight
obesity
rigidity
ultrasound
Adipose Tissue
Adolescent
Adult
Body Composition
Brachial Artery
Carotid Arteries
Carotid Artery Diseases
Compliance
Female
Femoral Artery
Follow-Up Studies
Humans
Longitudinal Studies
Male
Risk Factors
To reference this document use:
http://resolver.tudelft.nl/uuid:9ac9757a-8259-49f2-8df5-540480bbf49f
DOI
https://doi.org/10.1210/jc.2003-031619
TNO identifier
280228
ISSN
0021-972X
Source
Journal of Clinical Endocrinology and Metabolism, 89 (6), 2632-2639
Document type
article