Title
Transcriptomic coordination in the human metabolic network reveals links between n-3 fat intake, adipose tissue gene expression and metabolic health
Author
Morine, M.J.
Tierney, A.C.
van Ommen, B.
Daniel, H.
Toomey, S.
Gjelstad, I.M.F.
Gormley, I.C.
Pérez-Martinez, P.
Drevon, C.A.
López-Miranda, J.
Roche, H.M.
Publication year
2011
Abstract
Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to pathway analysis, we have developed a joint multivariate and network-based approach to analysis of a dataset of habitual dietary records, adipose tissue transcriptomics and comprehensive plasma marker profiles from human volunteers with the Metabolic Syndrome. With this approach we identified prominent co-expressed sub-networks in the global metabolic network, which showed correlated expression with habitual n-3 PUFA intake and urinary levels of the oxidative stress marker 8-iso-PGF2a. These sub-networks illustrated inherent cross-talk between distinct metabolic pathways, such as between triglyceride metabolism and production of lipid signalling molecules. In a parallel promoter analysis, we identified several adipogenic transcription factors as potential transcriptional regulators associated with habitual n-3 PUFA intake. Our results illustrate advantages of network-based analysis, and generate novel hypotheses on the transcriptomic link between habitual n-3 PUFA intake, adipose tissue function and oxidative stress. © 2011 Morine et al.
Subject
EELS - Earth, Environmental and Life Sciences
Life
Nutrition
MSB - Microbiology and Systems Biology
To reference this document use:
http://resolver.tudelft.nl/uuid:8e8da14d-1e9b-431d-abc1-74101a3be0d2
DOI
https://doi.org/10.1371/journal.pcbi.1002223
TNO identifier
442988
ISSN
1553-734X
Source
PLoS Computational Biology, 7 (7)
Document type
article