Print Email Facebook Twitter Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: A prospective, case-controlled observational study Title Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: A prospective, case-controlled observational study Author Bakker, L.E.H. Boon, M.R. van der Linden, R.A.D. Arias-Bouda, L.P. van Klinken, J.B. Smit, F. Verberne, H.J. Jukema, J.W. Tamsma, J.T. Havekes, L.M. van Marken Lichtenbelt, W.D. Jazet, I.M. Rensen, P.C.N. Publication year 2014 Abstract Background: Individuals of south Asian origin have a very high risk of developing type 2 diabetes compared with white Caucasians. We aimed to assess volume and activity of brown adipose tissue (BAT), which is thought to have a role in energy metabolism by combusting fatty acids and glucose to produce heat and might contribute to the difference in incidence of type 2 diabetes between ethnic groups. Methods: We enrolled Dutch nationals with south Asian ancestry and matched Caucasian participants at The Rijnland Hospital (Leiderdorp, Netherlands). Eligible participants were healthy lean men aged 18-28 years, and we matched groups for BMI. We measured BAT volume and activity with cold-induced 18F-fluorodeoxyglucose (18F-FDG) PET CT scans, and assessed resting energy expenditure, non-shivering thermogenesis, and serum parameters. This study is registered with the Netherlands Trial Register, number 2473. Findings: Between March 1, 2013, and June 1, 2013, we enrolled 12 participants in each group; one Caucasian participant developed hyperventilation after 18F-FDG administration, and was excluded from all cold-induced and BAT measurements. Compared with Caucasian participants, south Asian participants did not differ in age (mean 23·6 years [SD 2·8] for south Asians vs 24·6 years [2·8] for Caucasians) or BMI (21·5 kg/m2 [2·0] vs 22·0 kg/m2 [1·6]), but were shorter (1·74 m [0·06] vs 1·85 m [0·04]) and lighter (65·0 kg [8·5] vs 75·1 kg [7·2]). Thermoneutral resting energy expenditure was 1297 kcal per day (SD 123) in south Asian participants compared with 1689 kcal per day (193) in white Caucasian participants (difference -32%, p=0·0008). On cold exposure, shiver temperature of south Asians was 2·0°C higher than Caucasians (p=0·0067) and non-shivering thermogenesis was increased by 20% in white Caucasians (p<0·0001) but was not increased in south Asians. Although the maximum and mean standardised uptake values of 18F-FDG in BAT did not differ between groups, total BAT volume was lower in south Asians (188 mL [SD 81]) than it was in Caucasians (287 mL ; difference -34%, p=0·04). Overall, BAT volume correlated positively with basal resting energy expenditure in all assessable individuals (β=0·44, p=0·04). Interpretation: Lower resting energy expenditure, non-shivering thermogenesis, and BAT volumes in south Asian populations might underlie their high susceptibility to metabolic disturbances, such as obesity and type 2 diabetes. Development of strategies to increase BAT volume and activity might help prevent and treat such disorders, particularly in south Asian individuals. © 2014 Elsevier Ltd. Chemicals/CAS: fluorodeoxyglucose f 18, 63503-12-8; glucose, 50-99-7, 84778-64-3 Subject LifeMHR - Metabolic Health ResearchELSS - Earth, Life and Social SciencesBiomedical InnovationBiologyHealthy LivingFatty acidFluorodeoxyglucose f 18GlucoseAdultAnalytical parametersBrown adipose tissueCase control studyCaucasianComputer assisted tomographyControlled studyEnergy metabolismEthnic differenceEthnic groupEthnicityHumanHuman tissueIncidenceNon insulin dependent diabetes mellitusObservational studyOutcome assessmentProspective studySouth AsianTissue volume To reference this document use: http://resolver.tudelft.nl/uuid:8e7c9424-4588-48b5-bddd-b04813aa52de DOI https://doi.org/10.1016/s2213-8587(13)70156-6 TNO identifier 507097 ISSN 2213-8587 Source The Lancet Diabetes and Endocrinology, 2 (3), 210-217 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.