Title
Connecting the Human Variome Project to nutrigenomics
Author
Kaput, J.
Evelo, C.T.
Perozzi, G.
van Ommen, B.
Cotton, R.
TNO Kwaliteit van Leven
Publication year
2010
Abstract
Nutrigenomics is the science of analyzing and understanding gene-nutrient interactions, which because of the genetic heterogeneity, varying degrees of interaction among gene products, and the environmental diversity is a complex science. Although much knowledge of human diversity has been accumulated, estimates suggest that ~90% of genetic variation has not yet been characterized. Identification of the DNA sequence variants that contribute to nutrition-related disease risk is essential for developing a better understanding of the complex causes of disease in humans, including nutrition-related disease. The Human Variome Project (HVP; http://www.humanvariomeproject.org/ ) is an international effort to systematically identify genes, their mutations, and their variants associated with phenotypic variability and indications of human disease or phenotype. Since nutrigenomic research uses genetic information in the design and analysis of experiments, the HVP is an essential collaborator for ongoing studies of gene-nutrient interactions. With the advent of next generation sequencing methodologies and the understanding of the undiscovered variation in human genomes, the nutrigenomic community will be generating novel sequence data and results. The guidelines and practices of the HVP can guide and harmonize these efforts. © 2010 Springer-Verlag.
Subject
Physiological Sciences
Harmonization
Human Variome Project
Nutrigenomics
To reference this document use:
http://resolver.tudelft.nl/uuid:8c90547d-69f6-4e25-bef7-f8d392e11902
DOI
https://doi.org/10.1007/s12263-010-0186-6
TNO identifier
425690
ISSN
1555-8932
Source
Genes and Nutrition, 5 (4), 275-283
Document type
article