Print Email Facebook Twitter Effect of moderate alcohol consumption on adipokines and insulin sensitivity in lean and overweight men: A diet intervention study Title Effect of moderate alcohol consumption on adipokines and insulin sensitivity in lean and overweight men: A diet intervention study Author Beulens, J.W.J. de Zoete, E.C. Kok, F.J. Schaafsma, G. Hendriks, H.F.J. TNO Kwaliteit van Leven Publication year 2008 Abstract Objective: Moderate alcohol consumption is associated with a decreased risk of type II diabetes. This study investigates the effect of moderate alcohol consumption on adipokines and insulin sensitivity. Subjects: Twenty healthy, lean (body mass index (BMI) 18.5-25 kg/m2; n=11) or overweight (BMI>27 kg/m2; n=9) men (18-25 years). Methods: Three cans of beer (40g alcohol) or alcohol-free beer daily during 3 weeks. Results: Adiponectin and ghrelin concentrations increased (P<0.01) by 11 and 8%, while acylation-stimulating protein (ASP) concentrations decreased by 12% (P=0.04) after moderate alcohol consumption. Concentrations of leptin and resistin remained unchanged. Insulin sensitivity by an oral glucose tolerance test (OGTT) was not affected by moderate alcohol consumption, but 2h glucose concentrations were lower (P=0.01) after beer (4.5±0.1 mmol/l) than alcohol-free beer (4.9±0.1 mmol/l). Both free fatty acids and glucagon concentrations showed a stronger increase (P<0.01) after 90min during OGTT after beer than alcohol-free beer. Changes of adiponectin were positively correlated (r=0.69, P<0.001), and changes of leptin (r=-0.53, P=0.016) and ASP (r=-0.43, P=0.067) were negatively correlated with changes of insulin sensitivity index. All these results did not differ between lean and overweight men. Conclusions: Moderate alcohol consumption increased adiponectin and ghrelin, while it decreased ASP concentrations both in lean and overweight men. These changes are in line with the hypothesized improvement of insulin sensitivity, but did not affect insulin sensitivity within 3 weeks of moderate alcohol consumption. Subject Healthy for LifeHealthHealthy LivingPhysiological SciencesAcylation stimulating proteinAdipocytokineFatty acidGhrelinGlucagonGlucoseLeptinResistinAdultAlcohol consumptionArticleBeerBody massClinical articleControlled studyDiet therapyDisease associationGlucose blood levelHumanInsulin sensitivityIntervention studyLean body weightMaleNon insulin dependent diabetes mellitusObesityOral glucose tolerance testProtein analysisProtein expressionRisk reductionAcylationAdipokinesAdolescentAdultAlcohol DrinkingBeerBody Mass IndexBody WeightGhrelinGlucose Tolerance TestHumansInsulin ResistanceLipidsMaleOverweightThinnessYoung Adult To reference this document use: http://resolver.tudelft.nl/uuid:8a7de21c-5ddf-46f2-9019-fb21c6f24d19 DOI https://doi.org/10.1038/sj.ejcn.1602821 TNO identifier 241016 ISSN 0954-3007 Source European Journal of Clinical Nutrition, 62 (9), 1098-1105 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.