The role of analytical sciences in medical systems biology

article


Greef, J. van der

Stroobant, P.

Heijden, R. van der
Medical systems biology has generated widespread interest because of its bold conception and exciting potential, but the field is still in its infancy. Although there has been tremendous progress achieved recently in generating, integrating and analysing data in the medical and pharmaceutical field, many challenges remain, especially with respect to the crucial core technologies required for analytical characterization. This review briefly summarizes these aspects for metabolomics, proteomics, data handling and multivariate biostatistics.
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Analytical researchCapillary electrophoresisCEECDElectrochemical detectorHigh resolution magic angle spinningHR-MASMALDIMatrix-assisted laser desorption ionizationBiological markerCarbon 13Stable isotopeAnalytic methodArabidopsisAtherosclerosisBacillus subtilisBiostatisticsCarbon nuclear magnetic resonanceData analysisDiagnostic procedureDrug industryElectrochemical detectionHumanInfrared spectroscopyLiquid chromatographyMass spectrometerMass spectrometryMatrix assisted laser desorption ionization time of flight mass spectrometryNonhumanNuclear magnetic resonanceProteomicsReviewBiological MarkersComputational BiologyHumansMetabolismMolecular BiologyMultivariate AnalysisProteomicsSystems BiologyTechnology, PharmaceuticalArabidopsisBacillus subtilis
TNO Identifier
238040
Repository link
https://resolver.tno.nl/uuid:815450cc-16c1-4d3c-af53-b699ab8ddae9
ISSN
13675931
Source
Current Opinion in Chemical Biology, 8(5), pp. 559-565.
Pages
559-565
Files
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