Title
Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study
Author
Stegehuis, P.L.
Boogerd, L.S.F.
Inderson, A.
Veenendaal, R.A.
van Gerven, P.
Bonsing, B.A.
Sven Mieog, J.
Amelink, A.
Veselic, M.
Morreau, H.
van de Velde, C.J.H.
Lelieveldt, B.P.F.
Dijkstra, J.
Robinson, D.J.
Vahrmeijer, A.L.
Publication year
2017
Abstract
Endoscopic ultrasound-guided fine needle aspirations (EUS-FNA) of pancreatic masses suffer from sample errors and low-negative predictive values. Fiber-optic spectroscopy in the visible to near-infrared wavelength spectrum can noninvasively extract physiological parameters from tissue and has the potential to guide the sampling process and reduce sample errors. We assessed the feasibility of single fiber (SF) reflectance spectroscopy measurements during EUS-FNA of pancreatic masses and its ability to distinguish benign from malignant pancreatic tissue. A single optical fiber was placed inside a 19-gauge biopsy needle during EUS-FNA and at least three reflectance measurements were taken prior to FNA. Spectroscopy measurements did not cause any related adverse events and prolonged procedure time with ∼5min. An accurate correlation between spectroscopy measurements and cytology could be made in nine patients (three benign and six malignant). The oxygen saturation and bilirubin concentration were significantly higher in benign tissue compared with malignant tissue (55% versus 21%, p=0.038; 166umol/L versus 17umol/L, p=0.039, respectively). To conclude, incorporation of SF spectroscopy during EUS-FNA was feasible, safe, and relatively quick to perform. The optical properties of benign and malignant pancreatic tissue are different, implying that SF spectroscopy can potentially guide the FNA sampling.
Subject
TS - Technical Sciences
Nano Technology
Industrial Innovation
High Tech Systems & Materials
Pancreas
Cytology
Drug products
Endoscopy
Infrared devices
Optical fibers
Optical properties
Physiological models
Reflection
Spectroscopy
Ultrasonics
Fiber-optic spectroscopy
Fine-needle aspirations
Negative predictive value
Physiological parameters
Reflectance spectroscopy
Single fiber
Spectroscopy measurements
OPT - Optics
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http://resolver.tudelft.nl/uuid:7f65336d-4e92-444d-ba17-99fb2b89a01e
TNO identifier
745924
Publisher
SPIE
ISSN
1083-3668
Source
Journal of Biomedical Optics, 22 (22)
Document type
article