Print Email Facebook Twitter Dermal exposure assessment to benzene and toluene using charcoal cloth pads Title Dermal exposure assessment to benzene and toluene using charcoal cloth pads Author van Wendel de Joode, B. Tielemans, E. Vermeulen, R. Wegh, H. Kromhout, H. TNO Kwaliteit van Leven Publication year 2005 Abstract Charcoal cloth pads have been used to assess volatile chemicals on the skin in a laboratory setting; however, they have not yet been applied to measure dermal exposure in occupational settings. This study aimed at evaluating whether charcoal pads can be used to assess dermal exposure to benzene and toluene in workers of a petrochemical plant. Inhalation and dermal exposure levels to benzene and toluene were assessed for workers of a petrochemical plant performing different jobs. Benzene uptake was assessed by determining S-phenylmercapturic acid in workers' urine samples. Dermal exposure levels on the charcoal pads were adjusted for ambient air levels of benzene and toluene by subtracting the amount of benzene or toluene measured in personal air from the amount of benzene or toluene measured on the charcoal pad. In general, measured external and internal exposure levels were low. The estimated contribution of the dermal route to internal benzene exposure levels was less than 0.06% for all jobs. Toluene personal air concentrations and benzene and toluene dermal exposure levels differed statistically significantly between job titles. For benzene, differences between jobs were larger for adjusted dermal exposures (maximum 17-fold, P = 0.02) than for inhalation exposures (maximum two-fold, P = 0.08). Also for toluene, although less clear, differences between jobs were larger for adjusted dermal exposures (maximum 23-fold, P = 0.01) as compared to inhalation exposures (maximum 10-fold, P = 0.01). Charcoal pads appeared to measure dermal exposures to benzene and toluene in addition to ambient air levels. Future studies applying charcoal cloth pads for the dermal exposure assessment at workplaces with higher dermal exposure to organic solvents may provide more insight into the biological relevance of dermal exposure levels measured by charcoal cloth pads. In addition, the design of the dermal sampler might be improved by configuring a dermal sampler, where part of the sampler is protected against direct contact and splashes, but still permeable for the gas phase. This design would most likely result in a better ability to correct for airborne concentrations at a given body location. Subject HealthFood and Chemical Risk AnalysisBenzeneCharcoal cloth padsDermal exposureTolueneacetylcysteine derivativebenzenecharcoalorganic solventtolueneairborne particleambient airarticleclothingconcentration (parameters)drug blood levelhumanindustrial workerinhalationjob analysisoccupational exposureoccupational hazardoccupational toxicologypersonal monitoringpetrochemical industryskin absorptionAdministration, CutaneousBenzeneCharcoalChemical IndustryEnvironmental ExposureEnvironmental MonitoringHumansJob DescriptionOccupational ExposurePermeabilityPetroleumTolueneVolatilization To reference this document use: http://resolver.tudelft.nl/uuid:7c4f4df1-6efe-4c53-84ba-92a0b463f56e DOI https://doi.org/10.1038/sj.jea.7500349 TNO identifier 238301 ISSN 1053-4245 Source Journal of Exposure Analysis and Environmental Epidemiology, 15 (1), 47-50 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.