Title
Repeated exposure to furfural vapour: 13-week study in syrian golden hamsters
Author
Feron, V.J.
Kruysse, A.
Dreef Van Der Meulen, H.C.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1979
Abstract
The sub-acute inhalation toxicity of furfural was studied in Syrian golden hamsters. Four groups of ten males and ten females each were repeatedly exposed to furfural vapour at concentrations of 0, 20, 115 and 552 ppm (0, 77,448 and 2165 mg/m3 air) respectively for 6 hours/day, 5 days/week during a period of 13 weeks. At the highest exposure level furfural induced irritation of the eyes and nose, slight growth retardation and atrophy along with hyperplasia of the olfactory epithelium in the nasal cavity. At 115 ppm atrophy and hyperplasia of the olfactory epithelium were the only adverse effects observed that could be attributed to furfural. No compound-related alterations were detected at the lowest exposure concentration of 20 ppm (77 mg/m3 air) which was, therefore, accepted as a no-toxic effect level. Chemicals/CAS: furfural, 98-01-1; Furaldehyde, 98-01-1
Subject
Furfural
Animal experiment
Cigarette smoking
Drug toxicity
Eye
Histology
Inhalational drug administration
Intoxication
Nose
Nose mucosa
Olfactory epithelium
Olfactory system
Respiratory system
Syrian hamster
Toxicity
Visual system
Animal
Atrophy
Epithelium
Female
Furaldehyde
Hamsters
Male
Mesocricetus
Olfactory Mucosa
Plants, Toxic
Smoke
Smoking
Tobacco
Volatilization
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TNO identifier
228748
Source
Zentralblatt fur Bakteriologie. Hygiene. Krankenhaushygiene Betriebshygiene Praventive Medizin - Abt. 1 Orig. B, 168 (5-6), 442-451
Document type
article