Print Email Facebook Twitter Repeated exposure to furfural vapour: 13-week study in syrian golden hamsters Title Repeated exposure to furfural vapour: 13-week study in syrian golden hamsters Author Feron, V.J. Kruysse, A. Dreef Van Der Meulen, H.C. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1979 Abstract The sub-acute inhalation toxicity of furfural was studied in Syrian golden hamsters. Four groups of ten males and ten females each were repeatedly exposed to furfural vapour at concentrations of 0, 20, 115 and 552 ppm (0, 77,448 and 2165 mg/m3 air) respectively for 6 hours/day, 5 days/week during a period of 13 weeks. At the highest exposure level furfural induced irritation of the eyes and nose, slight growth retardation and atrophy along with hyperplasia of the olfactory epithelium in the nasal cavity. At 115 ppm atrophy and hyperplasia of the olfactory epithelium were the only adverse effects observed that could be attributed to furfural. No compound-related alterations were detected at the lowest exposure concentration of 20 ppm (77 mg/m3 air) which was, therefore, accepted as a no-toxic effect level. Chemicals/CAS: furfural, 98-01-1; Furaldehyde, 98-01-1 Subject FurfuralAnimal experimentCigarette smokingDrug toxicityEyeHistologyInhalational drug administrationIntoxicationNoseNose mucosaOlfactory epitheliumOlfactory systemRespiratory systemSyrian hamsterToxicityVisual systemAnimalAtrophyEpitheliumFemaleFuraldehydeHamstersMaleMesocricetusOlfactory MucosaPlants, ToxicSmokeSmokingTobaccoVolatilization To reference this document use: http://resolver.tudelft.nl/uuid:73483538-b60c-4698-939a-36613bd1e53e TNO identifier 228748 Source Zentralblatt fur Bakteriologie. Hygiene. Krankenhaushygiene Betriebshygiene Praventive Medizin - Abt. 1 Orig. B, 168 (5-6), 442-451 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.