Print Email Facebook Twitter The prognosis of chronic low back pain is determined by changes in pain and disability in the initial period Title The prognosis of chronic low back pain is determined by changes in pain and disability in the initial period Author Heymans, M.W. van Buuren, S. Knol, D.L. Anema, J.R. van Mechelen, W. de Vet, H.C.W. TNO Kwaliteit van Leven Publication year 2010 Abstract Background context: The recovery of patients with chronic low back pain (LBP) is slow. Furthermore, it is recently proposed that chronic LBP needs a prognostic approach to determine who will develop clinically significant back pain. Therefore, it is imperative to identify prognostic factors that are mostly seen in chronic LBP patients at an early stage. This may give clinicians tailored advice to prevent chronicity or may refer to a specific intervention. Purpose: To investigate the contribution of demographic, work, clinical, and psychosocial variables, including new prognostic variables as changes in pain intensity and disability status, on the development of chronic LBP. Study design/setting: Prospective cohort data by merging data from three randomized trials (secondary analyses). Patient sample: Workers (n=628) on sick leave because of subacute nonspecific LBP. Outcome measures: Chronic LBP for longer than 6 months (functional measure). Methods: Potential prognostic variables were demographic, work, clinical, and psychosocial characteristics (self-report measures). We also included as prognostic variables a clinically relevant change in pain intensity and disability status. For the selection of variables and prognostic models, bootstrapping techniques were used in combination with multivariable logistic regression. The explained variance and discrimination were used to evaluate the clinical performance of the models. Results: The variables most strongly related to chronic LBP were as follows: no clinically relevant change in pain intensity and in disability status in the first 3 months, a higher pain intensity score at baseline, and a higher score for kinesiophobia. This prognostic model had a bootstrap-corrected explained variance of 37% and a discriminative ability (c index) of 0.80. Conclusions: Clinical-, work-, and psychosocial-related variables contribute to the development of chronic LBP. The most promising variables are a clinically relevant decrease in pain intensity and in disability status in the first 3 months. These variables are relevant for clinicians to advise their patients with respect to preventive measures or treatment strategies. © 2010 Elsevier Inc. All rights reserved. Subject HealthLeefomgeving en gezondheidBootstrappingChronic painLow back painPrognosisProspective cohort study To reference this document use: http://resolver.tudelft.nl/uuid:6db298f5-fbb2-4cfd-82b2-59e4ee7e1a91 TNO identifier 409830 ISSN 1529-9430 Source Spine Journal, 10 (10), 847-856 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.