Title
Evidence for the occurrence of a fast-acting inhibitor for tissue-type plasminogen activator in human plasma
Author
Verheijen, J.H.
Chang, G.T.G.
Kluft, C.
Gaubius Instituut TNO
Publication year
1984
Abstract
Human plasma contains a fast-acting t-PA inhibitor, which is not identical with ??2-antiplasmin or ??2-macroglobulin. The concentration of this inhibitor in normal plasma is highly variable, much lower than that of known plasma protease inhibitors, and in the range of physiologically occurring plasma concentrations of t-PA (0-2 IU/ml). The inhibitor binds to concanavalin A-Sepharose, is rather stable when heated, is not precipitated in euglobulin fractions and probably does not originate from platelets. The inhibitor seems to form a 190 Kd complex with t-PA. The relation between this plasma inhibitor and the recently discovered endothelial cell inhibitor is not yet clear. Chemicals/CAS: plasminogen activator, 9039-53-6; Glycoproteins; Iodine Radioisotopes; Plasminogen Activators, EC 3.4.21.-; Plasminogen Inactivators
Subject
plasminogen activator
blood and hemopoietic system
human
inhibitor
plasma
Chromatography, Affinity
Electrophoresis, Polyacrylamide Gel
Glycoproteins
Human
Iodine Radioisotopes
Kinetics
Molecular Weight
Plasminogen Activators
Plasminogen Inactivators
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TNO identifier
229582
ISSN
0340-6245
Source
Thrombosis and Haemostasis, 51 (3), 392-395
Document type
article