Title
Nanomaterials and the serosal immune system in the thoracic and peritoneal cavities
Author
Kuper, C.F.
Pieters, R.H.H.
van Bilsen, J.H.M.
Publication year
2021
Abstract
The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid cells (ILCs) are found abundantly in the thoracic and peritoneal cavities, and they are crucial in first defense against pathogenic viruses and bacteria. Nanomaterials (NMs) can enter the cavities intentionally for medical purposes, or unintentionally following environmental exposure; subsequent serosal inflammation and cancer (mesothelioma) has gained significant interest. However, reports on adverse effects of NM on ILCs and other components of the serosal immune system are scarce or even lacking. As ILCs are crucial in the first defense against pathogenic viruses and bacteria, it is possible that serosal exposure to NM may lead to a reduced resistance against pathogens. Additionally, affected serosal lymphoid tissues and cells may disturb adipose tissue homeostasis. This review aims to provide insight into key effects of NM on the serosal immune system. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Subject
FALC
Innate lymphocytes
MS
Pericardium
Peritoneum
Pleura
SALC
Serosa
nanomaterial
nanomaterial
adaptive immunity
adipose tissue
environmental exposure
human
immune system
immunocompetent cell
innate immunity
lung mucosa
lymphoid cell
lymphoid tissue
mesothelioma
peritoneal cavity
Review
serosa
serositis
thoracic cavity
animal
chemistry
homeostasis
immune system
immunology
inflammation
lymphocyte
peritoneal cavity
physiology
serosa
thoracic cavity
Animals
Homeostasis
Humans
Immune System
Inflammation
Lymphocytes
Nanostructures
Peritoneal Cavity
Serous Membrane
Thoracic Cavity
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http://resolver.tudelft.nl/uuid:6cf06afb-8dad-4246-ab08-e7f24025a0b5
DOI
https://doi.org/10.3390/ijms22052610
TNO identifier
967980
Source
International Journal of Molecular Sciences, 22 (22), 1-15
Document type
article