Print Email Facebook Twitter Ghrelin response to carbohydrate-enriched breakfast is related to insulin Title Ghrelin response to carbohydrate-enriched breakfast is related to insulin Author Blom, W.A.M. Stafleu, A. de Graaf, C. Kok, F.J. Schaafsma, G. Hendriks, H.F.J. TNO Kwaliteit van Leven Publication year 2005 Abstract Background: Ghrelin plays an important role in the regulation of food intake. Little is known about how ghrelin concentrations are modified by dietary factors. Objective: We examined the effects of both amount and type of carbohydrate on ghrelin concentrations and all correlations among the variables ghrelin, glucose, insulin, leptin, and all 4 subjective measures of appetite. Design: Twenty healthy nonobese men were studied in a double-blind, randomized, crossover design. Subjective measures of appetite and concentrations of ghrelin, glucose, insulin, and leptin were frequently assessed for 4 h after liquid breakfast meals differing in energy content and carbohydrate structure-ie, water, low-calorie (LC) meal, high-calorie simple carbohydrate (HC-SC) meal, and high-calorie complex carbohydrate (HC-CC) meal. Results: Ghrelin concentrations decreased after the HC-SC breakfast by 41%, after the HC-CC breakfast by 33%, and after the LC breakfast by 24%. No significant differences in ghrelin concentration among the 3 breakfasts were observed until 120 min. Ghrelin concentrations were correlated with subjective measures of hunger (r = 0.51) and fullness (r = -0.44). The percentage decrease in ghrelin between 0 and 30 min was inversely correlated with the percentage increases in insulin (r = -0.76) and glucose (r= -0.79) but not with changes in leptin (r = 0.10). The percentage changes in ghrelin concentrations between 30 and 180 min were correlated with the percentage changes in insulin (r= -0.53) and leptin (r= -0.47) but not with changes in glucose (r = 0.22). Conclusion: The results support the hypothesis that ghrelin requires postgastric feedback, which may be regulated through insulin. © 2005 American Society for Clinical Nutrition. Subject HealthBiomedical ResearchAppetiteBreakfastCarbohydrateGhrelinGlucoseHungerInsulinLeptinLiquidMenSatiationSatietyVisual analogue scalesghrelinglucoseinsulinleptincarbohydratepeptide hormoneadultappetitearticlecaloric intakecarbohydrate analysiscarbohydrate dietcontrolled studyglucose blood levelhormone responsehumanhuman experimentinsulin blood levellow calory dietmacronutrientmalemealnormal humanpostprandial stateanalysis of variancearea under the curvebloodchemistryclinical trialcontrolled clinical trialcrossover proceduredietary fiberdouble blind proceduredrug effectfat intakemetabolismmiddle agedphysiologyrandomized controlled trialAdultAnalysis of VarianceAppetiteArea Under CurveBlood GlucoseCarbohydratesCross-Over StudiesDietary CarbohydratesDietary FatsDietary FiberDouble-Blind MethodHumansInsulinLeptinMaleMiddle AgedPeptide HormonesPostprandial Period To reference this document use: http://resolver.tudelft.nl/uuid:6b9f205b-af9c-401f-bc78-c34997b216d3 TNO identifier 238927 ISSN 0002-9165 Source American Journal of Clinical Nutrition, 81 (2), 367-375 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.