Title
Dose-Response Relationship of a Web-Based Tailored Intervention Promoting Human Papillomavirus Vaccination: Process Evaluation of a Randomized Controlled Trial
Author
Pot, M.
Paulussen, T.G.
Ruiter, R.A.
Hofstra, M.
van Keulen, H.M.
Publication year
2020
Abstract
Background: In the Netherlands, human papillomavirus (HPV) vaccination uptake remains low. To improve informed decision making (IDM) and HPV vaccination acceptability, we systematically developed an interactive, web-based tailored intervention to which mothers of Dutch girls were invited to participate. Objective: The aim of this study was to provide insight into the intervention's working mechanisms by evaluating (1) program use, (2) program acceptability, and (3) the relationship of program use with program acceptability and intervention effects (ie, dose-response relationship). Methods: Only mothers from the intervention arm of a randomized controlled trial that assessed the effectiveness of the web-based, tailored intervention were included in this study. They were invited to visit the website of the web-based intervention between baseline (January 2015, just before access to the intervention) and follow up (March 2015, prior to the first HPV vaccination). Indicators for program use were time of website use (ie, duration of intervention exposure) and completeness (ie, proportion of all available web pages visited). HPV vaccination uptake registered by Praeventis was used as the primary outcome. Secondary outcomes were IDM, decisional conflict, and social-psychological determinants of HPV vaccination uptake. Results: Among the 3995 invited mothers, 2509 (62.80%) logged on to the website, 2239 of whom (89.24%) visited at least one page of the intervention components. On average, mothers spent 21.39 minutes (SD 12.41) on the website and completed 50.04% (SD 26.18%) of the website components. Participants rated the website 7.64 (SD 1.39) on a 10-point scale. Program acceptability was significantly associated with completeness (β=4.36, P
Subject
Randomized controlled trial
HPV vaccination
Dose-response relationship
Informed decision making
Intervention use
Process evaluation
Web-based tailored intervention
Healthy for Life
Healthy Living
Life
CH - Child Health
ELSS - Earth, Life and Social Sciences
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http://resolver.tudelft.nl/uuid:6aa8cfcc-1987-41b1-a6eb-74ce697b3dcd
DOI
https://doi.org/10.2196/14822
TNO identifier
946484
Source
Journal of Medical Internet Research, 22 (22), e14822
Document type
article