Print Email Facebook Twitter Glutathione conjugation as a bioactivation reaction Title Glutathione conjugation as a bioactivation reaction Author van Bladeren, P.J. Centraal Instituut voor Voedingsonderzoek TNO Publication year 2000 Abstract In general, glutathione conjugation is regarded as a detoxication reaction. However, depending on the properties of the substrate, bioactivation is also possible. Four types of activation reaction have been recognized: direct-acting compounds, conjugates that are activated through cysteine conjugate beta-lyase, conjugates that are activated through redox cycling and lastly conjugates that release the original reactive parent compound. The glutathione S-transferases have three connections with the formation of biactivated conjugates: they catalyze their formation in a number of cases, they are the earliest available target for covalent binding by these conjugates and lastly, the parent alkylating agents are regularly involved in the induction of the enzymes. Individual susceptibility for each of these agents is determined by individual transferase subunit composition and methods are becoming available to assess this susceptibility. © 2000 Elsevier Science Ireland Ltd. Chemicals/CAS: Carbon-Sulfur Lyases, EC 4.4.-; Glutathione Transferase, EC 126.96.36.199; Glutathione, 70-18-8; S-alkylcysteine lyase, EC 188.8.131.52; Xenobiotics Subject NutritionBioactivationGlutathione conjugatesGlutathione S-transferasesCysteineGlutathioneGlutathione transferaseLyaseCatalysisChemical bindingChemical reactionChromosomal localizationConjugationCovalent bondDetoxificationEnzyme activationEnzyme activityEnzyme inductionEnzyme inhibitionEnzyme mechanismGene locationGenetic polymorphismHumanNonhumanProtein expressionReaction analysisReductionAnimalsBiotransformationCarbon-Sulfur LyasesEnzyme InductionGlutathioneGlutathione TransferaseHumansMetabolic Detoxication, DrugOxidation-ReductionXenobiotics To reference this document use: http://resolver.tudelft.nl/uuid:6a6d9ed0-cb90-45ea-add1-eba265260625 DOI https://doi.org/10.1016/s0009-2797(00)00214-3 TNO identifier 56919 ISSN 0009-2797 Source Chemico-Biological Interactions, 129 (1-2), 61-76 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.