Title
Distribution and excretion of TEGDMA in guinea pigs and mice
Author
Reichl, F.X.
Durner, J.
Hickel, R.
Kunzelmann, K.H.
Jewett, A.
Wang, M.Y.
Spahl, W.
Kreppel, H.
Moes, G.W.H.
Kehe, K.
Walther, U.
Forth, W.
Hume, W.R.
Publication year
2001
Abstract
The monomer triethyleneglycoldimethacrylate (TEGDMA) is used as a diluent in many resin-based dental materials. It was previously shown in vitro that TEGDMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of 14C-TEGDMA applied via gastric, intradermal, and intravenous administration at dose levels well above those encountered in dental care were examined in vivo in guinea pigs and mice as a test of the hypothesis that TEGDMA reaches cytotoxic levels in mammalian tissues. 14C-TEGDMA was taken up rapidly from the stomach and small intestine after gastric administration in both species and was widely distributed in the body following administration by each route. Most 14C was excreted within one day as 14CO2. The peak equivalent TEGDMA levels in all mouse and guinea pig tissues examined were at least 1000-fold less than known toxic levels. The study therefore did not support the hypothesis.
Subject
Macrogol derivative
Polymethacrylic acid derivative
Resin
Triethylene glycol dimethacrylate
Animal
Bagg albino mouse
Digestive tract intubation
Female
Guinea pig
Intravenous drug administration
Male
Metabolic clearance rate
Metabolism
Mouse
Subcutaneous drug administration
Tissue distribution
Composite resins
Injections, Intravenous
Injections, Subcutaneous
Intubation, Gastrointestinal
Mice
Mice, Inbred BALB C
Polyethylene glycols
Polymethacrylic acids
Triethylene glycol dimethacrylate, 109-16-0
Polymethacrylic acids
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DOI
https://doi.org/10.1177/00220345010800050501
TNO identifier
953576
ISSN
0022-0345
Source
Journal of Dental Research, 80 (80), 1412-1415
Document type
article