Print Email Facebook Twitter Metabolomics-based systems biology and personalized medicine: Moving towards n = 1 clinical trials? Title Metabolomics-based systems biology and personalized medicine: Moving towards n = 1 clinical trials? Author van der Greef, J. Hankemeier, T. McBurney, R.N. TNO Kwaliteit van Leven Publication year 2006 Abstract Personalized medicine - defined as customized medical care for each patient's unique condition - in the broader context of personalized health, will make significant strides forward when a systems approach is implemented to achieve the ultimate in disease phenotyping and to create novel therapeutics that address system-wide molecular perturbations caused by disease processes. Combination drug therapies with individualized optimization are likely to become a major focus. Metabolomics incorporates the most advanced approaches to molecular phenotype system readout and provides the ideal theranostic technology platform for the discovery of biomarker patterns associated with healthy and diseased states, for use in personalized health monitoring programs and for the design of individualized interventions. © 2006 Future Medicine Ltd. Subject BiologyAnalytical researchIntegrative medicineMetabolomicsPersonalized medicinePhenotypingSystems biologygefitinibimatinibparacetamoltrastuzumabatherosclerosisdisease courseenvironmental factorgas chromatographygenotypehumanischemic heart diseaselifestyleliquid chromatographyliver injurymass spectrometrymedical caremetabolitemetabolomicsmolecular mechanicsnon insulin dependent diabetes mellitusnonhumannuclear magnetic resonance spectroscopynutritional statusoral glucose tolerance testphenotypepsychological aspectreviewsystems biologyAnimalsClinical TrialsHumansMetabolismResearch DesignSystems Biology To reference this document use: http://resolver.tudelft.nl/uuid:5c4ba6f8-100f-4a00-8231-d07bd05f7de5 DOI https://doi.org/10.2217/146224188.8.131.527 TNO identifier 239519 ISSN 1462-2416 Source Pharmacogenomics, 7 (7), 1087-1094 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.