Print Email Facebook Twitter Consumption of vegetables and fruits and risk of subtypes of head-neck cancer in the Netherlands Cohort Study Title Consumption of vegetables and fruits and risk of subtypes of head-neck cancer in the Netherlands Cohort Study Author Maasland, D.H.E. van den Brandt, P.A. Kremer, B. Goldbohm, R.A. Schouten, L.J. Publication year 2015 Abstract There is limited prospective data on the relationship between consumption of vegetables and fruits and the risk of head-neck cancer (HNC) subtypes [i.e., oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC) and laryngeal cancer (LC)]. Therefore, we investigated these associations within the Netherlands Cohort Study, in which 120,852 participants completed a 150-item food frequency questionnaire at baseline in 1986. After 20.3 years of follow-up, 415 cases of HNC (131 OCC, 88 OHPC, three oral cavity/pharynx unspecified or overlapping and 193 LC) and 3,898 subcohort members were available for case-cohort analysis using Cox proportional hazards models. Total vegetable and fruit consumption was inversely associated with risk of HNC overall [multivariable-adjusted rate ratios for highest vs. lowest quartile: 0.61, 95% confidence interval (CI) 0.44-0.85, p trend 0.002] and all HNC subtypes, with the strongest associations for OCC. Total vegetable intake and total fruit intake were also associated with a decreased risk of HNC overall and HNC subtypes. No significant interaction was found between vegetable and fruit intake and alcohol consumption or cigarette smoking. In conclusion, in this large-scale cohort study, consumption of vegetables and fruits was associated with a decreased risk of HNC overall and all subtypes. Consumption of vegetables and fruits (or of specific groups of them) may protect against HNC and its subtypes. Subject LifeLS - Life StyleELSS - Earth, Life and Social SciencesHealthy for LifeHealthHealthy LivingCohort studiesEtiologyFruitsHead-neck cancerVegetablesAdultAgedAlcohol consumptionCancer riskCohort analysisDietary intakeFemaleHead and neck cancerHumanHypopharynx cancerLarynx cancerMajor clinical studyMaleMouth cancerNetherlandsOropharynx cancerProspective studyRisk assessmentRisk reductionSmoking To reference this document use: http://resolver.tudelft.nl/uuid:59565584-133b-4c1f-9f80-2274569c81b1 DOI https://doi.org/10.1002/ijc.29219 TNO identifier 521634 ISSN 0020-7136 Source International Journal of Cancer, 136 (5), E396-E409 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.