Print Email Facebook Twitter The international collaboration on air pollution and pregnancy outcomes: Initial results Title The international collaboration on air pollution and pregnancy outcomes: Initial results Author Parker, J.D. Rich, D.Q. Glinianaia, S.V. Leem, J.H. Wartenberg, D. Bell, M.L. Bonzini, M. Brauer, M. Darrow, L. Gehring, U. Gouveia, N. Grillo, P. Ha, E. van den Hooven, E.H. Jalaludin, B. Jesdale, B.M. Lepeule, J. Morello-Frosch, R. Morgan, G.G. Slama, R. Pierik, F.H. Pesatori, A.C. Sathyanarayana, S. Seo, J. Strickland, M. Tamburic, L. Woodruff, T.J. Publication year 2011 Abstract Background: The findings of prior studies of air pollution effects on adverse birth outcomes are difficult to synthesize because of differences in study design. Objectives: The International Collaboration on Air Pollution and Pregnancy Outcomes was formed to understand how differences in research methods contribute to variations in findings. We initiated a feasibility study to a) assess the ability of geographically diverse research groups to analyze their data sets using a common protocol and b) perform location-specific analyses of air pollution effects on birth weight using a standardized statistical approach. Methods: Fourteen research groups from nine countries participated. We developed a protocol to estimate odds ratios (ORs) for the association between particulate matter = 10 µm in aerodynamic diameter (PM10) and low birth weight (LBW) among term births, adjusted first for socioeconomic status (SES) and second for additional location-specific variables. Results: Among locations with data for the PM10 analysis, ORs estimating the relative risk of term LBW associated with a 10-µg/m3 increase in average PM10 concentration during pregnancy, adjusted for SES, ranged from 0.63 [95% confidence interval (CI), 0.30-1.35] for the Netherlands to 1.15 (95% CI, 0.61-2.18) for Vancouver, with six research groups reporting statistically significant adverse associations. We found evidence of statistically significant heterogeneity in estimated effects among locations. Conclusions: Variability in PM10-LBW relationships among study locations remained despite use of a common statistical approach. A more detailed meta-analysis and use of more complex protocols for future analysis may uncover reasons for heterogeneity across locations. However, our findings confirm the potential for a diverse group of researchers to analyze their data in a standardized way to improve understanding of air pollution effects on birth outcomes. Subject Earth & EnvironmentUES - Urban Environment & SafetyEELS - Earth, Environmental and Life SciencesEnvironmentAir pollutionBirth weightICAPPOLow birth weightParticulate matterPregnancy To reference this document use: http://resolver.tudelft.nl/uuid:592f8c29-228f-4711-8ad3-b92179c62d16 TNO identifier 431400 ISSN 0091-6765 Source Environmental Health Perspectives, 119 (7), 1023-1028 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.