Title
The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays
Author
Vinken, M.
Doktorova, T.
Ellinger-Ziegelbauer, H.
Ahr, H.-J.
Lock, E.
Carmichael, P.
Roggen, E.
van Delft, J.
Kleinjans, J.
Castell, J.
Bort, R.
Donato, T.
Ryan, M.
Corvi, R.
Keun, H.
Ebbels, T.
Athersuch, T.
Sansone, S.-A.
Rocca-Serra, P.
Stierum, R.
Jennings, P.
Pfaller, W.
Gmuender, H.
Vanhaecke, T.
Rogiers, V.
TNO Kwaliteit van Leven
Publication year
2008
Abstract
Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The Sixth Framework Program project carcinoGENOMICS was specifically raised to develop omics-based in vitro screens for testing the carcinogenic potential of chemical compounds in a pan-European context. This paper provides an in-depth analysis of the complexity of choosing suitable reference compounds used for creating and fine-tuning the in vitro carcinogenicity assays. First, a number of solid criteria for the selection of the model compounds are defined. Secondly, the strategy followed, including resources consulted, is described and the selected compounds are briefly illustrated. Finally, limitations and problems encountered during the selection procedure are discussed. Since selecting an appropriate set of chemicals is a frequent impediment in the early stages of similar research projects, the information provided in this paper might be extremely valuable. Crown Copyright © 2008.
Subject
Biology
Physiological Sciences
carcinoGENOMICS
Chemical carcinogenesis
FP6 project
Genomics
Genotoxic carcinogen
Metabolomics
Metabonomics
Model compounds
Non-genotoxic carcinogen
REACH
Selection criteria
1,3 butadiene
2 nitrofluorene
2,3,7,8 tetrachlorodibenzo para dioxin
aflatoxin B1
alkanone
arsenate sodium
asbestos
benzo[a]pyrene
bromodichloromethane
cadmium derivative
chemical compound
chloroprene
chlorothalonil
dichromate sodium
dimethylnitrosamine
isobutyl nitrite
methapyrilene
monuron
nifedipine
ochratoxin
phenobarbital
phorbol 13 acetate 12 myristate
piperonyl butoxide
pirinixic acid
potassium bromate
s (1,2 dichlorovinyl)cysteine
streptozocin
tolbutamide
unindexed drug
vinyl chloride
carcinogenicity
genomics
human
in vitro study
medical information
medical research
model
nonhuman
priority journal
review
screening
Animal Testing Alternatives
Carcinogenicity Tests
European Union
Gene Expression Profiling
Genomics
Hazardous Substances
International Cooperation
Toxicogenetics
Animalia
To reference this document use:
http://resolver.tudelft.nl/uuid:591fd53a-c3b2-4723-a765-2f551c0b9009
DOI
https://doi.org/10.1016/j.mrrev.2008.04.006
TNO identifier
240979
ISSN
1383-5742
Source
Mutation Research - Reviews in Mutation Research, 659 (3), 202-210
Document type
article