Print Email Facebook Twitter Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome Title Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome Author Visser, J.T.J. de Kloet, E. Nagelkerken, L. TNO Preventie en Gezondheid Publication year 2000 Abstract It is increasingly recognized that glucocortiocoids (GCs) can have subtle modulatory effects in immunoregulation rather than having generalized immunosuppressive effects. GCs suppress Th1 cells and cellular immunity, but may favor Th2 responses and humoral immunity. The chronic fatigue syndrome (CFS) appears to be associated with a disturbed HPA-axis. Moreover, CFS patients show several immunological changes suggestive of decreased cellular immunity. It is postulated herein that in CFS patients a decreased Th1/Th2 balance may be the result of selective effects of GC on the IL-10/IL-12 regulatory circuit. Chemicals/CAS: Glucocorticoids Subject Interleukin 10Interleukin 12Autoimmune diseaseCellular immunityChronic fatigue syndromeConference paperHumoral immunityHypothalamus hypophysis adrenal systemImmune responseImmunomodulationNeuroendocrinologyTh1 cellTh2 cellFatigue Syndrome, ChronicGlucocorticoidsHumansImmunityNeuroimmunomodulation To reference this document use: http://resolver.tudelft.nl/uuid:559d151b-98e0-4e11-a201-1639dfc5a607 TNO identifier 235899 ISSN 0077-8923 Source Annals of the New York Academy of Sciences, 917, 868-875 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.