Title
Toxicity of formaldehyde and acrolein mixtures: In vitro studies using nasal epithelial cells
Author
Cassee, F.R.
Stenhuis, W.S.
Groten, J.P.
Feron, V.J.
Instituut CIVO-Toxicologie en Voeding TNO
Publication year
1996
Abstract
In vitro studies with human and rat nasal epithelial cells were carried out to investigate the combined toxicity of formaldehyde and acrolein and the role of aldehyde dehydrogenases in this process. These studies showed that the toxic effect of mixtures of aldehydes was additive. In addition, aldehyde dehydrogenases were inhibited by disulfiram and acrolein in S9 incubation but disulfiram did not influence the toxicity in vitro (cell culture). This study does not support the idea that aldehyde dehydrogenases play a major role in the detoxification of exogenous aldehydes. Chemicals/CAS: Acrolein, 107-02-8; Aldehyde Dehydrogenase, EC 1.2.1.3; Formaldehyde, 50-00-0
Subject
Toxicology
Acrolein
Aldehyde Dehydrogenase
Animals
Cell Line
Cell Survival
Epithelium
Formaldehyde
Humans
Nasal Mucosa
Rats
Animalia
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TNO identifier
84813
ISSN
0940-2993
Source
Experimental and Toxicologic Pathology, 48 (6), 481-483
Document type
article