Print Email Facebook Twitter An amino acid polymorphism in histidine-rich glycoprotein (HRG) explains 59% of the variance in plasma HRG levels Title An amino acid polymorphism in histidine-rich glycoprotein (HRG) explains 59% of the variance in plasma HRG levels Author Hennis, B.C. Boomsma, D.I. van Boheemen, P.A. Engesser, L. Kievit, P. Dooijewaard, G. Kluft, C. TNO Preventie en Gezondheid Publication year 1995 Abstract A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual environmental factors of 27%. These results are remarkably similar to the results found in a previous parent-twin study in which a heritability of 69% and an effect of random environment of 31% was found. The overall genetic influence in the present study can be subdivided into an effect of 59% by the HRG phenotype and 11% by residual genetic factors. The influence of the HRG phenotype of 59% can entirely be explained by adding up the effect of the two alleles that make up the phenotype. These results indicate a codominant inheritance pattern of HRG levels in which the genetic influence can almost completely be ascribed to the additive effect of the di-allelic HRG locus whereas only a small part is due to other loci. Subject Biologyglycoproteinhistidineadultagearticleblood levelcontrolled studyenvironmental factorgenetic polymorphismhumaninheritancemajor clinical studymaximum likelihood methodnormal humanpedigreepriority journalAllelesAmino AcidsAnalysis of VarianceBlood ProteinsCase-Control StudiesChromosome MappingGlycoproteinsHumansLikelihood FunctionsMolecular WeightPedigreePhenotypePolymorphism, GeneticProteins To reference this document use: http://resolver.tudelft.nl/uuid:4d75d279-ea24-453f-83bd-88fd7cb8a375 TNO identifier 233073 ISSN 0340-6245 Source Thrombosis and Haemostasis, 74 (6), 1497-1500 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.