Title
The effects of 4-aminopyridine on cognitive function in patients with multiple sclerose: A pilot study
Author
Smits, R.C.F.
Emmen, H.H.
Bertelmans, F.W.
Kulig, B.M.
van Loenen, A.C.
Polman, C.H.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1994
Abstract
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function. Chemicals/CAS: 4-Aminopyridine, 504-24-5; Placebos
Subject
4 Aminopyridine
Clinical article
Clinical trial
Cognition
Controlled clinical trial
Controlled study
Crossover procedure
Double blind procedure
Hearing test
Multiple sclerosis
Neuropsychological test
Oral drug administration
Randomized controlled trial
Task performance
Verbal memory
Visual memory
4-Aminopyridine
Adult
Aged
Cognition Disorders
Double-Blind Method
Female
Humans
Male
Middle Aged
Multiple Sclerosis
Neuropsychological Tests
Pilot Projects
Placebos
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TNO identifier
36538
Source
Neurology, 44, 1701-1705
Document type
article