Email Facebook Twitter Research goals for folate and related B vitamin in Europe Title Research goals for folate and related B vitamin in Europe Author Finglas, P.M. de Meer, K. Molloy, A. Verhoef, P. Pietrzik, K. Powers, H.J. van der Straeten, D. Jägerstad, M. Varela-Moreiras, G. van Vliet, T. Havenaar, R. Buttriss, J. Wright, A.J.A. TNO Kwaliteit van Leven Publication year 2006 Abstract In the past decade, the understanding of folate bioavailability, metabolism and related health issues has increased, but several problems remain, including the difficulty of delivering the available knowledge to the populations at risk. Owing to the low compliance of taking folic acid supplements, for example, among women of child-bearing age who could lower the risk of having a baby with a neural tube defect, food-based strategies aimed at increasing the intake of folate and other B-group vitamins should be a priority for future research. These should include the development of a combined strategy of supplemental folate (possibly with vitamin B12), biofortification using engineered plant-derived foods and micro-organisms and food fortification for increasing folate intakes in the general population. Currently, the most effective population-based strategy to reduce NTDs remains folic acid fortification. However, the possible adverse effect of high intakes of folic acid on neurologic functioning among elderly persons with vitamin B12 deficiency needs urgent investigation. The results of ongoing randomized controlled studies aimed at reducing the prevalence of hyperhomocysteinemia and related morbidity must be available before food-based total population approaches for treatment of hyperhomocysteinemia can be recommended. Further research is required on quantitative assessment of folate intake and bioavailability, along with a more thorough understanding of physiological, biochemical and genetic processes involved in folate absorption and metabolism. © 2006 Nature Publishing Group All rights reserved. Subject NutritionBiomedical ResearchCancerFolateFoodFortificationHomocysteineNeural tube defectcyanocobalaminfolic acidvitamin B grouparticlebioavailabilitycancer preventioncardiovascular diseasecardiovascular riskclinical trialcolorectal cancercost benefit analysiscyanocobalamin deficiencydiabetes mellitusdiet supplementationdietary intakedisease associationelderly careenzyme polymorphismfeasibility studyfood analysisfood biotechnologyfood compositiongene interactionhealth hazardhigh risk populationhumanhyperhomocysteinemiahyperlipidemiahypertensionin vivo studymalabsorptionmorbidityneural tube defectnutritional statusnutritional valueosteoporosispatient compliancepregnancyprevalencequantitative analysisrisk assessmentrisk factorrisk reductionsmokingstomach pHuterine cervix cancervitamin metabolismvitamin supplementationBiological AvailabilityFolic AcidFood TechnologyFood, FortifiedHumansHyperhomocysteinemiaIntestinal AbsorptionNeural Tube DefectsVitamin B 12Vitamin B Complex To reference this document use: http://resolver.tudelft.nl/uuid:417c9461-a104-4807-ae49-3bf08a91fccd DOI https://doi.org/10.1038/sj.ejcn.1602315 TNO identifier 239120 ISSN 0954-3007 Source European Journal of Clinical Nutrition, 60 (2), 287-294 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.