Title
Metabolism of ATP-binding cassette drug transporter inhibitors: Complicating factor for multidrug resistance.
Author
Cnubben, N.H.
Wortelboer, H.M.
van Zanden, J.J.
Rietjens, I.M.
van Bladeren, P.J.
TNO Kwaliteit van Leven
Publication year
2005
Abstract
Membrane transport proteins belonging to the ATP-binding cassette (ABC) family of transport proteins play a central role in the defence of organisms against toxic compounds, including anticancer drugs. However, for compounds that are designed to display a toxic effect, this defence system diminishes their effectiveness. This is typically the case in the development of cellular resistance to anticancer drugs. Inhibitors of these transporters are thus potentially useful tools to reverse this transporter-mediated cellular resistance to anticancer drugs and, eventually, to enhance the effectiveness of the treatment of patients with drug-resistant cancer. This review highlights the various types of inhibitors of several multidrug resistance-related ABC proteins, and demonstrates that the metabolism of inhibitors, as illustrated by recent data obtained for various natural compound inhibitors, may have considerable implications for their effect on drug transport and their potential for treatment of drug resistance.
Subject
Health Pharmacology
Physiological Sciences
ABC transporter
cyclosporin derivative
dibenzo[a,d]cycloheptene derivative
glycoprotein P
quinoline derivative
valspodar
zosuquidar
drug antagonism
drug design
drug effect
genetics
human
metabolism
multidrug resistance
review
RNA interference
transport at the cellular level
ATP-Binding Cassette Transporters
Biological Transport
Cyclosporins
Dibenzocycloheptenes
Drug Design
Drug Resistance, Multiple
Humans
P-Glycoproteins
Quinolines
RNA Interference
To reference this document use:
http://resolver.tudelft.nl/uuid:3e4c2a55-5dbd-4060-8396-40324ab05e79
TNO identifier
238623
ISSN
1742-5255
Source
Expert opinion on drug metabolism & toxicology., 1 (2), 219-232
Document type
article