Title
Short-chain fructo-oligosaccharides improve magnesium absorption in adolescent girls with a low calcium intake
Author
van den Heuvel, E.G.H.M.
Muijs, T.
Brouns, F.
Hendriks, H.F.J.
TNO Kwaliteit van Leven
Publication year
2009
Abstract
Consumption of fructo-oligosaccharides (FOS) has been shown to improve mineral absorption in the short term, but no long-term effects were studied in girls with a low calcium intake. Therefore, we hypothesized that short- and long-term consumption of short-chain FOS (sc-FOS) improves calcium and magnesium absorption in girls with a low habitual calcium intake. Fourteen girls aged between 12 and 14 years received, for 36 days, 10 g sc-FOS (sc-FOS) or maltodextrin (placebo). Short-chain FOS were taken daily for 8 days followed by an intermittent intake mode on 28 random days to mimic noncontinuous intake. In a crossover design, true calcium and magnesium absorption was computed on the 8th and 36th day of each treatment period from isotope enrichment in urine. In addition, the parathyroid hormone and vitamin D in serum and markers of bone resorption in urine (pyridinoline and deoxypyridinoline) were determined. Short-chain FOS increased magnesium absorption by 18% after 36 days (30.1% ± 9.1% vs 35.4% ± 12.8%). Magnesium absorption did not change after the initial 8 days of long-term sc-FOS intake. Short-chain FOS did not affect calcium absorption. In addition, sc-FOS did not affect vitamin D, parathyroid hormone, or markers of bone resorption. It is concluded that consumption of sc-FOS for 36 days stimulated magnesium absorption in girls but did not affect calcium absorption. © 2009 Elsevier Inc. All rights reserved.
Subject
Health
Biomedical Research
Adolescents
Calcium
Dual stable isotope technique
Fructo-oligosaccharides
Magnesium
True absorption
calcium
deoxypyridinoline
fructose oligosaccharide
isotope
magnesium
maltodextrin
parathyroid hormone
placebo
pyridinoline
vitamin D
adolescent
article
bone metabolism
calcium absorption
calcium intake
calcium metabolism
carbohydrate intake
child
clinical trial
controlled clinical trial
controlled study
crossover procedure
double blind procedure
female
human
magnesium metabolism
normal human
osteolysis
parathyroid hormone blood level
priority journal
randomized controlled trial
school child
treatment duration
urine
vitamin blood level
Absorption
Adolescent
Amino Acids
Bone Resorption
Calcium
Child
Cross-Over Studies
Double-Blind Method
Female
Humans
Magnesium
Oligosaccharides
Parathyroid Hormone
Polysaccharides
Vitamin D
To reference this document use:
http://resolver.tudelft.nl/uuid:3db62cd7-294b-4770-9aba-03d1fe2b689d
DOI
https://doi.org/10.1016/j.nutres.2009.03.005
TNO identifier
241450
ISSN
0271-5317
Source
Nutrition Research, 29 (4), 229-237
Document type
article