Title
Job Strain and the risk of stroke: An individual-participant data meta-analysis
Author
Fransson, E.I.
Nyberg, S.T.
Heikkilä, K.
Alfredsson, L.
Bjorner, J.B.
Borritz, M.
Burr, H.
Dragano, N.
Geuskens, G.A.
Goldberg, M.
Hamer, M.
Hooftman, W.E.
Houtman, I.L.
Joensuu, M.
Jokela, M.
Knutsson, A.
Koskenvuo, M.
Koskinen, A.
Kumari, M.
Leineweber, C.
Lunau, T.
Madsen, I.E.H.
Hanson, L.L.M.
Nielsen, M.L.
Nordin, M.
Oksanen, T.
Pentti, J.
Pejtersen, J.H.
Rugulies, R.
Salo, P.
Shipley, M.J.
Steptoe, A.
Suominen, S.B.
Theorell, T.
Toppinen-Tanner, S.
Vahtera, J.
Virtanen, M.
Väänänen, A.
Westerholm, P.J.M.
Westerlund, H.
Zins, M.
Britton, A.
Brunner, E.J.
Singh-Manoux, A.
Batty, G.D.
Kivimäki, M.
Publication year
2015
Abstract
BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain. METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke. RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status. CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.
Subject
Life
WHC - Work, Health and Care
ELSS - Earth, Life and Social Sciences
Work and Employment
Workplace
Healthy Living
Psychological
Stress
Stroke
Work
Brain hemorrhage
Brain ischemia
Cerebrovascular accident
Cohort analysis
Disease association
Follow up
Human
Job stress
Meta analysis
Priority journal
Prospective study
Risk assessment
Social status
To reference this document use:
http://resolver.tudelft.nl/uuid:3cbe7a6e-0683-4421-89a9-49d8ece3151f
DOI
https://doi.org/10.1161/strokeaha.114.008019
TNO identifier
523249
ISSN
0039-2499
Source
Stroke, 46 (2), 557-559
Document type
article