Print Email Facebook Twitter Job Strain and the risk of stroke: An individual-participant data meta-analysis Title Job Strain and the risk of stroke: An individual-participant data meta-analysis Author Fransson, E.I. Nyberg, S.T. Heikkilä, K. Alfredsson, L. Bjorner, J.B. Borritz, M. Burr, H. Dragano, N. Geuskens, G.A. Goldberg, M. Hamer, M. Hooftman, W.E. Houtman, I.L. Joensuu, M. Jokela, M. Knutsson, A. Koskenvuo, M. Koskinen, A. Kumari, M. Leineweber, C. Lunau, T. Madsen, I.E.H. Hanson, L.L.M. Nielsen, M.L. Nordin, M. Oksanen, T. Pentti, J. Pejtersen, J.H. Rugulies, R. Salo, P. Shipley, M.J. Steptoe, A. Suominen, S.B. Theorell, T. Toppinen-Tanner, S. Vahtera, J. Virtanen, M. Väänänen, A. Westerholm, P.J.M. Westerlund, H. Zins, M. Britton, A. Brunner, E.J. Singh-Manoux, A. Batty, G.D. Kivimäki, M. Publication year 2015 Abstract BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain. METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke. RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status. CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies. Subject LifeWHC - Work, Health and CareELSS - Earth, Life and Social SciencesWork and EmploymentWorkplaceHealthy LivingPsychologicalStressStrokeWorkBrain hemorrhageBrain ischemiaCerebrovascular accidentCohort analysisDisease associationFollow upHumanJob stressMeta analysisPriority journalProspective studyRisk assessmentSocial status To reference this document use: http://resolver.tudelft.nl/uuid:3cbe7a6e-0683-4421-89a9-49d8ece3151f DOI https://doi.org/10.1161/strokeaha.114.008019 TNO identifier 523249 ISSN 0039-2499 Source Stroke, 46 (2), 557-559 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.