Title
Complex mixtures: Relevance of combined exposure to substances at low dose levels
Author
Leeman, W.R.
Krul, L.
Houben, G.F.
Publication year
2013
Abstract
Upon analysis of chemically complex food matrices a forest of peaks is likely to be found. Identification of these peaks and concurrent determination of the toxicological relevance upon exposure is very time consuming, expensive and often requires animal studies. Recently, a safety assessment framework based on the Threshold of Toxicological Concern (TTC) was published to assess the safety of chemically complex matrices more efficiently. In this safety assessment framework, the toxicological relevance of exposure to unidentified substances in chemically complex food matrices can be related to the Cramer class III TTC threshold, currently set at 90. μg/day. However, possible additive or synergistic effects of combined exposure is not covered.The current evaluation describes the relevance of combined low dose exposure to unidentified substances in chemically complex food matrices. It is concluded that to some extent cumulative effects at exposure levels for each substance at or below the Cramer class III TTC threshold, being present in a complex mixture including food, might occur. However the health relevance of possible cumulative effects at this dose level is considered to be that low that a need for a correction factor to cover possible cumulative effects is very low to absent. © 2013 Elsevier Ltd.
Subject
Life
QS - Quality & Safety
EELS - Earth, Environmental and Life Sciences
Food and Nutrition
Nutrition
Healthy Living
Chemically complex food matrices
Complex mixtures
Cumulative effects
Mixture toxicity
Risk assessment
Threshold of Toxicological Concern
TTC
To reference this document use:
http://resolver.tudelft.nl/uuid:357242ab-926e-4ec5-9b91-e14157908ea2
DOI
https://doi.org/10.1016/j.fct.2013.03.050
TNO identifier
472184
Source
Food and Chemical Toxicology, 58, 141-148
Document type
article