Title
Raman Spectroscopy as a Promising Tool for Noninvasive Point-of-Care Glucose Monitoring
Author
Scholtes-Timmerman, M.J.
Bijlsma, S.
Fokkert, M.J.
Slingerland, R.
van Veen, S.J.F.
Publication year
2014
Abstract
Self-monitoring of glucose is important for managing diabetes. Noninvasive glucose monitors are not yet available, but patients would benefit highly from such a device. We present results that may lead to a novel, point-of-care noninvasive system to measure blood glucose based on Raman spectroscopy. A hospitalized cohort of 111 subjects was measured using a custommade Raman spectrometer system. Blood glucose reference samples were used to correlate Raman data to glucose levels, using advanced preprocessing and analysis algorithms. A correlation coefficient (R2) of .83 was found correlating independent Raman-based predictions on reference blood glucose for the full cohort. Stratification of the cohort in gender-specific groups raised correlation levels to .88 (females) and .94 (males). Glucose could be measured noninvasively with average errors as low as 0.9 mM. We conclude that this novel system shows promising results for the advance of noninvasive, point-of-care glucose monitoring.
Subject
Life Earth / Environmental
RAPID - Risk Assessment Products in Development AEC - Applied Environmental Chemistry
ELSS - Earth, Life and Social Sciences
Food and Nutrition
Nutrition
Healthy Living
Blood glucose
Noninvasive
Point of care
Raman spectroscopy
Self-monitoring of blood glucose
Analysis
Blood glucose monitoring
Devices
Glucose blood level
Hospital information system
Procedures
Very elderly
Adult
Aged
Aged, 80 and over
Blood Glucose Self-Monitoring
Female
Humans
Male
Middle Aged
Monitoring, Physiologic
Point-of-Care Systems
Spectrum Analysis, Raman
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http://resolver.tudelft.nl/uuid:34a42ca9-67f2-46b2-afeb-86f5e1cdcc1e
DOI
https://doi.org/10.1177/1932296814543104
TNO identifier
507738
Source
Journal of Diabetes Science and Technology, 8 (5), 1354-1361
Document type
article