Title
Salinomycin-induced polyneuropathy in cats: Morphologic and epidemiologic data
Author
van der Linde-Sipman, J.S.
van den Inch, T.S.G.A.M.
van Nes, J.J.
Verhagen, H.
Kersten, J.G.T.M.
Beynen, A.C.
Plekkringa, R.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1999
Abstract
In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory at motor nerves.
Subject
Nutrition
Cat
Peripheral nervous system
Polyneuropathy
Salinomycin
Toxic
salinomycin
animal cell
animal food
animal lameness
article
food analysis
food contamination
motor nerve
nerve degeneration
nonhuman
paralysis
peripheral nerve
polyneuropathy
sensory nerve
Animal Feed
Animals
Cat Diseases
Cats
Coccidiostats
Disease Outbreaks
Female
Food Contamination
Forelimb
Hindlimb
Ionophores
Lameness, Animal
Male
Netherlands
Peripheral Nerves
Peripheral Nervous System Diseases
Pyrans
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http://resolver.tudelft.nl/uuid:277eea7d-8755-48a1-858c-5727d967c488
TNO identifier
235328
ISSN
0300-9858
Source
Veterinary Pathology, 36 (2), 152-156
Document type
article