Title
Genetic influences on fibrinogen, tissue plasminogen activator-antigen and von Willebrand factor in males and females
Author
de Lange, M.
de Geus, E.J.C.
Kluft, C.
Meijer, P.
van Doornen, L.J.P.
Boomsma, D.I.
Snieder, H.
TNO Kwaliteit van Leven
Publication year
2006
Abstract
Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in means and in genetic and/or environmental variance components of haemostatic risk factors for CHD. A total of 93 monozygotic twin pairs (44 male and 49 female) and 116 dizygotic twin pairs (36 male, 40 female and 40 opposite sex) were available for this study. Structural equation modelling was used to estimate the relative influence of genetic and environmental factors on variation in levels of fibrinogen, tissue plasminogen activator (tPA) antigen and von Willebrand factor (vWF). Mean levels of tPA vWF increased with age. Oral contraceptive pill (OCP) and menopause had significant influences on levels of fibrinogen and tPA. Genetic influences explained 39, 66 and 72% of the variation in levels of fibrinogen, tPA and vWF, respectively. No quantitative or qualitative differences of genetic influences on haemostatic levels were seen between males and females. Haemostatic factor may account for a significant part of the genetic risk for cardiovascular disease. No difference in genetic architecture for levels of fibrinogen, tPA or vWF was observed between males and females. © 2006 Schattauer GmbH, Stuttgart. Chemicals / CAS: fibrinogen, 9001-32-5; tissue plasminogen activator, 105913-11-9; von Willebrand factor, 109319-16-6; Biological Markers; Fibrinogen, 9001-32-5; Tissue Plasminogen Activator, EC 3.4.21.68; von Willebrand Factor
Subject
Biology
Biomedical Research
Haemostasis
Heritability
Oral contraceptive pill
Sex differences
Twins
Fibrinogen
Oral contraceptive agent
Tissue plasminogen activator
Von Willebrand factor
Blood sampling
Cardiovascular risk
Confidence interval
Controlled study
Correlation analysis
Dizygotic twins
Environmental factor
Female
Genetic predisposition
Genetic variability
Hemostasis
Heredity
Human
Human experiment
Ischemic heart disease
Male
Menopause
Monozygotic twins
Population distribution
Sex difference
Sex ratio
Statistical analysis
Statistical significance
Adult
Biological Markers
Coronary Disease
Female
Fibrinogen
Hemostasis
Humans
Male
Middle Aged
Risk Factors
Sex Factors
Tissue Plasminogen Activator
Twins, Dizygotic
Twins, Monozygotic
von Willebrand Factor
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DOI
https://doi.org/10.1160/th05-09-0596
TNO identifier
239150
ISSN
0340-6245
Source
Thrombosis and Haemostasis, 95 (3), 414-419
Document type
article