Title
The effect of plant sterols and different low doses of omega-3 fatty acids from fish oil on lipoprotein subclasses
Author
Jacobs, D.M.
Mihaleva, V.V.
van Schalkwijk, D.B.
de Graaf, A.A.
Vervoort, J.
van Dorsten, F.A.
Ras, R.T.
Demonty, I.
Trautwein, E.A.
van Duynhoven, J.
Publication year
2015
Abstract
Scope: Consumption of a low-fat spread enriched with plant sterols (PS) and different low doses (<2 g/day) of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish oil reduces serum triglycerides (TGs) and low-density lipoprotein-cholesterol (LDL-Chol) and thus beneficially affects two blood lipid risk factors. Yet, their combined effects on TG and Chol in various lipoprotein subclasses have been investigated to a limited extent. Methods and results: In a randomized, double-blind, placebo-controlled, parallel study, we determined TG and Chol in 13 LP subclasses in fasting serum of 282 hypercholesterolemic subjects, who consumed either a placebo spread or one of the four spreads containing PS (2.5 g/day) and EPA+DHA (0.0, 0.9, 1.3, and 1.8 g/day) for 4 weeks. After PS treatment, total LDL-Chol was reduced, which was not further changed by EPA+DHA. No shift in the LDL-Chol particle distribution was observed. The addition of EPA+DHA to PS dose-dependently reduced VLDL-Chol and VLDL-TG mainly in larger particles. Furthermore, the two highest doses of EPA+DHA increased Chol and TG in the larger HDL particles, while these concentrations were decreased in the smallest HDL particles. Conclusion: The consumption of a low-fat spread enriched with both PS and EPA+DHA induced shifts in the lipoprotein distribution that may provide additional cardiovascular benefits over PS consumption alone. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subject
Life
MSB - Microbiology and Systems Biology
ELSS - Earth, Life and Social Sciences
Food and Nutrition
Biology
Healthy Living
Lipoprotein
N-3 fatty acids
NMR
Particle Profiler
Plant sterols
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http://resolver.tudelft.nl/uuid:15c14e74-e5a7-4a9e-a98e-7fcfe0e58614
DOI
https://doi.org/10.1002/mnfr.201500152
TNO identifier
528432
ISSN
1613-4125
Source
Molecular Nutrition and Food Research, 59 (9), 1745-1757
Document type
article