Title
Low-grade inflammation, diet composition and health: Current research evidence and its translation
Author
Minihane, A.M.
Vinoy, S.
Russell, W.R.
Baka, A.
Roche, H.M.
Tuohy, K.M.
Teeling, J.L.
Blaak, E.E.
Fenech, M.
Vauzour, D.
McArdle, H.J.
Kremer, B.H.A.
Sterkman, L.
Vafeiadou, K.
Benedetti, M.M.
Williams, C.M.
Calder, P.C.
Publication year
2015
Abstract
The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch (ILSI Europe). It is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled 'Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies'. The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation-health/disease associations. The evidence relating diet composition and early-life nutrition to inflammatory status is reviewed. Human epidemiological and intervention data are thus far heavily reliant on the measurement of inflammatory markers in the circulation, and in particular cytokines in the fasting state, which are recognised as an insensitive and highly variable index of tissue inflammation. Potential novel kinetic and integrated approaches to capture inflammatory status in humans are discussed. Such approaches are likely to provide a more discriminating means of quantifying inflammation-health/disease associations, and the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims. Copyright © 2015 ILSI Europe. Chemicals/CAS: C reactive protein, 9007-41-4
Subject
ELSS - Earth, Life and Social Sciences
Life
Healthy Living
Biomedical Innovation
Biomarkers
Chronic diseases
Health claims
Low-grade inflammation
Bacterium lipopolysaccharide
Biological marker
C reactive protein
Chemokine
Flavonoid
Interleukin 6
Tumor necrosis factor alpha
Alzheimer disease
Atherosclerosis
Carbohydrate intake
Cardiovascular disease
Chronic disease
Chronic inflammation
Cytokine production
Degenerative disease
Diet
Endotoxemia
Fat intake
Human
Inflammation
Intestine flora
Maternal obesity
Mucosal immunity
Nervous system inflammation
Non insulin dependent diabetes mellitus
Nonalcoholic fatty liver
Nonhuman
Review
MSB - Microbiology and Systems Biology
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http://resolver.tudelft.nl/uuid:0ccba7fa-2cdb-4b57-b2ab-3ca93fdf009d
DOI
https://doi.org/10.1017/s0007114515002093
TNO identifier
528810
ISSN
0007-1145
Source
British Journal of Nutrition, 114 (114), 999-1012
Document type
article