Title
The bradykinin B2 receptor in the early immune response against Listeria infection
Author
TNO Defensie en Veiligheid
Kaman, W.E.
Wolterink, A.F.W.M.
Bader, M.
Boele, L.C.L.
van der Kleij, D.
Publication year
2009
Abstract
The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B2 (B2R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B2R (B2R-/- mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with Listeria monocytogenes. Levels of cytokines known to play a pivotal role in the early phase immune response against L. monocytogenes, IL-12p70 and IFN-γ, were reduced in B2R-/- mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells. Thus, we show that bradykinin and the B2R play a role in early innate immune functions during bacterial infection. © 2008 Springer-Verlag.
Subject
Bradykinin
Cytokines
Knock out mice
Listeria monocytogenes
Bradykinin B2 receptor
Gamma interferon
Interleukin 12p70
Animal experiment
Animal model
Article
Controlled study
Cytokine production
Dendritic cell
Immune response
Lsteria monocytogenes
Listeriosis
Monocyte
Mouse
Nonhuman
Priority journal
Protein function
Weight reduction
Animals
Body Weight
Bradykinin
Cells, Cultured
Cytokines
Dendritic Cells
Humans
Interferon-gamma
Interleukin-12
Listeria Infections
Listeria monocytogenes
Liver
Mice
Mice, Knockout
Receptor, Bradykinin B2
To reference this document use:
http://resolver.tudelft.nl/uuid:09332dd4-620d-46fb-a233-bf7c60d84992
DOI
https://doi.org/10.1007/s00430-008-0103-4
TNO identifier
241382
ISSN
0300-8584
Source
Medical Microbiology and Immunology, 198 (198), 39-46
Document type
article