Title
Endothelium specific matrilysin (MMP-7) expression in human cancers
Author
Sier, C.F.M.
Hawinkels, L.J.A.C.
Zijlmans, H.J.M.A.A.
Zuidwijk, K.
Muller, E.S.M.
Ferreira, V.
Hanemaaijer, R.
Mulder-Stapel, A.A.
Kenter, G.G.
Verspaget, H.W.
Gorter, A.
TNO Kwaliteit van Leven
Publication year
2008
Abstract
Over-expression of matrilysin (MMP-7) is predominantly associated with epithelial (pre)malignant cells. In the present study MMP-7 expression is also found in endothelial cells in various human cancer types. Endothelial MMP-7 was associated with CD34 and/or CD105 expression. These immunohistochemical data were confirmed by RT-PCR on VEGF-stimulated endothelial cells. In addition, MMP-7 was also identified in sprouting endothelial cells in vitro. The potential clinical relevance of endothelial MMP-7 was assessed for cervical cancer patients by evaluating the association with overall survival. In contrast to MMP-7 in malignant epithelial cells, MMP-7 expression in endothelial cells showed a significant association with poor survival (LR 5.12, P = 0.02, n = 30). Our data suggest that MMP-7 is involved in tumor angiogenesis, thereby contributing to malignant growth and hence associated with decreased survival. © 2007 International Society of Matrix Biology.
Subject
Health
Physiological Sciences
Angiogenesis
Breast
Carcinoma
Cervix
Colon
Matrix metalloproteinase
Prostate
Stomach
CD34 antigen
endoglin
matrilysin
vasculotropin
adult
aged
angiogenesis
antigen expression
article
cancer cell
cancer growth
cancer patient
cancer survival
endothelium cell
female
human
human cell
human tissue
immunohistochemistry
in vitro study
major clinical study
malignant neoplastic disease
priority journal
protein expression
reverse transcription polymerase chain reaction
tumor vascularization
uterine cervix cancer
Carcinoma
Cell Line, Tumor
Endothelium
Female
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Matrix Metalloproteinase 7
Neoplasm Invasiveness
Neovascularization, Pathologic
Spheroids, Cellular
Time Factors
Tissue Distribution
Umbilical Veins
Uterine Cervical Neoplasms
To reference this document use:
http://resolver.tudelft.nl/uuid:02cacb63-56d5-4c6b-897b-8cd0f02af338
DOI
https://doi.org/10.1016/j.matbio.2007.10.006
TNO identifier
240728
ISSN
0945-053X
Source
Matrix Biology, 27 (3), 267-271
Document type
article