Print Email Facebook Twitter Mid-frequency hearing loss and reduction of acoustic startle responding in rats following trichloroethylene exposure Title Mid-frequency hearing loss and reduction of acoustic startle responding in rats following trichloroethylene exposure Author Jaspers, R.M.A. Muijser, H. Lammers, J.H.C.M. Kulig, B.M. Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO Publication year 1993 Abstract Modification of auditory evoked startle responding using prepulse inhibition was used to examine the effects of trichloroethylene (TCE) exposure on auditory thresholds. Rats were exposed by inhalation to 0, 1500, or 3000 ppm TCE for 18 hours per day, 5 days a week for 3 weeks. Auditory thresholds for 5 and 20 kHz tones were measured before exposure and at 1, 3, and 6 weeks postexposure. In addition, hearing thresholds for 5 and 35 kHz tones were examined at a 5-week postexposure time-point. Results indicated that hearing thresholds for 20 kHz but not for 5 or 35 kHz prepulses were significantly increased in rats exposed to 3000 ppm TCE. These findings demonstrate a selective hearing loss in the 20 kHz range by short-term, high-level TCE exposure. With respect to effects on startle responding per se, the present study also found that compared to controls, TCE-exposed rats failed to show an increase in baseline startle with repeated testing. This difference could not be attributed to differences in body weight and was persistent throughout the postexposure period. Chemicals/CAS: Trichloroethylene, 79-01-6 Subject Acoustic startle responseOtotoxicitySolventsTrichloroethyleneTrichloroethyleneAnimal experimentAnimal modelAuditory stimulationControlled studyHearing lossNonhumanStartle reflexAcoustic StimulationAnimalAuditory ThresholdHearing Loss, BilateralRatsRats, WistarStartle ReactionSupport, Non-U.S. Gov'tTrichloroethyleneAnimalia To reference this document use: http://resolver.tudelft.nl/uuid:0123d5fa-8c6b-4f7d-ab98-c7091c52f200 DOI https://doi.org/10.1016/0892-0362(93)90058-v TNO identifier 67072 Source Neurotoxicology and Teratology, 15, 407-412 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.