Print Email Facebook Twitter Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters Title Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters Author Turnbull, D. Frankos, V.H. van Delft, J.H.M. de Vogel, N. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1999 Abstract Plant stanol esters from wood and vegetable oil sources were tested for genotoxicity in bacterial (Salmonella typhimurium) and mammalian cell (L5178Y) gene mutation assays and in a mammalian cell chromosome aberration assay (CHO cells). The two stanol ester formulations were tested separately at doses up to the limit of solubility, with and without the addition of an Aroclor-induced rat liver microsome metabolic activation system (S9 mix). All tests were performed in duplicate and gave negative results for both wood and vegetable oil stanol ester formulations. Thus, plant stanol esters are not genotoxic under the conditions of exposure tested. Subject NutritionFatty acid esterVegetable oilChemical structureChromosome aberrationFood safetyGene mutationGenotoxicityMammal cellPriority journalSalmonella typhimuriumWoodAnimalsCarcinogenicity TestsCHO CellsChromosome AberrationsCricetinaeDNA Mutational AnalysisEvaluation StudiesMiceMutagensPhytosterolsPlant OilsSalmonella typhimuriumTumor Cells, CulturedWoodBacteria (microorganisms)MammaliaSalmonella typhimuriumTyphimurium To reference this document use: http://resolver.tudelft.nl/uuid:fed6f01d-6058-4e84-9d9b-83386fc5395d DOI https://doi.org/10.1006/rtph.1999.1289 TNO identifier 235065 ISSN 0273-2300 Source Regulatory Toxicology and Pharmacology, 29 (2 I), 205-210 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.