Title
Safety profile of Hoodia gordonii extract: Mouse prenatal developmental toxicity study
Author
Dent, M.P.
Wolterbeek, A.P.M.
Russell, P.J.
Bradford, R.
Publication year
2012
Abstract
Hoodia gordonii extract (0, 5, 15 or 50. mg/kg body weight/day, n= 24 mice/group) was orally administered by gavage to female CD-1 mice from gestation days 5-17. On gestation day 18 the females were euthanized and examined. Treatment at 50. mg/kg/day caused a marked reduction in feed intake and body weight gain. Feed consumption was sporadically reduced at 15. mg/kg/day. At 50 or 15. mg/kg/day fetal weights, ossification of some bones and full and empty uterus weights were reduced. There were no clear maternal or fetal effects at 5. mg/kg/day. Reproductive indices were unaffected at all doses and there were no treatment-related malformations, anomalies or variations. The overall study no-observed-adverse-effect level was set at 5. mg/kg/day. In summary, at doses that reduced maternal feed consumption, H. gordonii extract delayed fetal development. The fetal effects seen could be consequent to reduced maternal feed consumption, the desired biological activity of the test item. © 2011 Elsevier Ltd.
Subject
Life
QS - Quality & Safety
EELS - Earth, Environmental and Life Sciences
Research
Healthy Living
Embryo-fetal development
Food safety
Functional food
Hoodia gordonii
Plant extract
Steroid glycosides
To reference this document use:
http://resolver.tudelft.nl/uuid:fdd9f037-0b8a-4001-bc55-8af1b7cf9968
DOI
https://doi.org/10.1016/j.fct.2011.06.017
TNO identifier
447269
ISSN
0278-6915
Source
Food and Chemical Toxicology, 50 (SUPPL. 1), S20-S25
Document type
article