Cyclopiazonic acid inhibits mutagenic action of aflatoxin B1
de Nijs-Tjon, L.
Cyclopiazonic acid and aflatoxin B1 are mycotoxins which can both be produced by the same moulds. Men can be exposed to these mycotoxins directly via ingestion of plant-derived food, as well as, indirectly via consumption of animal products. Although it is well known that aflatoxin B1 is mutagenic, contradictory results exist on the mutagenicity of cyclopiazonic acid. Using the Ames test cyclopiazonic acid was not found to be mutagenic either with or without metabolic activation by S9-mix of Arochlor treated rats. However, the mutagenicity of aflatoxin B1 was inhibited in the presence of cyclopiazonic acid. Since cyclopiazonic acid inhibited the formation of certain metabolites of caffeine and testosterone, it was concluded that the reduction of the mutagenicity of aflatoxin B1 in the presence of cyclopiazonic acid results from the inhibition of the bioactivation of aflatoxin B1 by certain cytochrome P450 enzymes.
To reference this document use:
Environmental Toxicology and Pharmacology, 11 (11), 207-212