Title
Tissue culture and neurotoxicology
Author
Hooisma, J.
Medisch Biologisch Laboratorium TNO
Publication year
1982
Abstract
Application of tissue culture in neurotoxicology may serve two purposes. First, they may be used to unravel the mechanism of action of neurotoxic compounds and secondly, they may be used for the screening of neurotoxic agents. Studies belonging to the first group can be subdivided into those aiming at the replication of neurotoxic processes in vivo and into those concerned with non-specific effects of neurotoxicants on cultured cells. The potential usefulness of these types of studies for the development of screening methods is discussed. An investigation of acrylamide neurotoxicity in cultures of cerebral cells serves to illustrate such an approach. Chemicals/CAS: acrylamide, 79-06-1; colchicine, 64-86-8; glutathione, 70-18-8; nicotinamide adenine dinucleotide, 53-84-9; Acrylamide, 79-06-1; Acrylamides; Colchicine, 64-86-8; Glutathione, 70-18-8; NAD, 53-84-9
Subject
Biology
Acrylamide
Colchicine
Glutathione
Nicotinamide adenine dinucleotide
Animal cell
Brain cell
Central nervous system
Dose response
Drug comparison
Drug mechanism
Drug mixture
Drug response
Drug screening
In vitro study
Intoxication
Methodology
Nervous system
Neurotoxicity
Nonhuman
Rat
Tissue culture
Acrylamide
Acrylamides
Animal
Axons
Colchicine
Female
Ganglia, Spinal
Glutathione
Male
NAD
Nervous System Diseases
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Tissue Culture
Toxicology
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TNO identifier
229278
ISSN
0275-1380
Source
Neurobehavioral Toxicology and Teratology, 4 (6), 617-622
Document type
article