Print Email Facebook Twitter Long-term effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity in healthy postmenopausal women Title Long-term effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity in healthy postmenopausal women Author van Baal, W.M. Kenemans, P. Emeis, J.J. Schalkwijk, C.G. Mijatovic, V. van der Mooren, M.J. Vischer, U.M. Stehouwer, C.D.A. Gaubius instituut TNO Publication year 1999 Abstract Objective: To study the effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity. Design: Prospective, randomized, controlled study. Setting: Academic hospital. Patient(s): Healthy postmenopausal women with an intact uterus. Intervention(s): For the first 12 months, the hormone replacement therapy group (n = 14) received oral E2, 1 mg daily, sequentially combined with 5 or 10 mg of dydrogesterone. Thereafter, they received oral E2, 2 mg daily, sequentially combined with 10 mg of dydrogesterone. The control group (n = 13) received no treatment. Data were collected at baseline and at 3, 12, and 15 months. Main Outcome Measure(s): Parameters of endothelial function and inflammatory activity. Result(s): During 12 months of follow-up, we observed decreases of 15% in plasma levels of endothelin-1, of 21% in soluble thrombomodulin, of 14% in von Willebrand factor, and of 12% in clottable fibrinogen in the hormone replacement therapy group compared with the control group. There was a 5% decrease in soluble E-selectin levels. All significant changes were observed by 3 months and sustained after 15 months. Brachial artery flow-mediated vasodilatation and C-reactive protein levels did not change significantly. Conclusion(s): Long-term combined hormone replacement therapy with E2 and dydrogesterone in healthy women was associated with sustained improvement in some aspects of endothelial function and in clottable fibrinogen levels. Subject HealthE- selectinEndothelial functionEndothelin-1EstrogenFibrinogenHormone replacement therapyInflammatory activityPostmenopausalThrombomodulinVon Willebrand factorC reactive proteinDydrogesteroneE-SelectinEndothelin-1Endothelium, VascularEstradiolEstrogen Replacement TherapyFemaleFibrinogenHumansInflammationMiddle AgedPostmenopauseProspective StudiesSolubilityThrombomodulinvon Willebrand Factor To reference this document use: http://resolver.tudelft.nl/uuid:fadd7691-8362-49e3-90a0-42fdc02173b5 DOI https://doi.org/10.1016/s0015-0282(98)00513-5 TNO identifier 234994 ISSN 0015-0282 Source Fertility and Sterility, 71 (4), 663-670 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.