Title
Semi-continuous high speed gas analysis of generated vapors of chemical warfare agents
Author
Trap, H.C.
Langenberg, J.P.
Department of Chemical Toxicology, TNO Prins Maurits Laboratory, P.O. Box 45, 2280 AA, Rijswijk, Netherlands
Publication year
1999
Abstract
A method is presented for the continuous analysis of generated vapors of the nerve agents soman and satin and the blistering agent sulfur mustard. By using a gas sampling valve and a very short (15 cm) column connected to an on-column injector with a 'standard length' column, the system can either be calibrated or used for performing high speed gas analyses. When using a flame ionization detector, the detection limit was ca. 100 ppb (ca. 0.5-1.0 mg/m3). This technique is applied in inhalation toxicokinetic studies of nerve agents and mustard gas in the guinea pig.
Subject
Automation
Data acquisition
Nerve agents
Sulfur mustard
Valve injection
Vapor analysis
Mustard gas
Nerve gas
Neurotoxin
Sarin
Soman
Analytic method
Animal experiment
Article
Autoanalysis
Chemical warfare
Chromatography
Gas analysis
Gas chromatography
Guinea pig
Neurotoxicity
Nonhuman
Toxicokinetics
Vapor
Mustard gas, 505-60-2
Neurotoxin, 39386-17-9
Sarin, 107-44-8
Soman, 96-64-0
To reference this document use:
http://resolver.tudelft.nl/uuid:fa4c7ad2-9a2c-4b13-80f0-c5b3fcf78eb7
TNO identifier
234882
ISSN
0935-6304
Source
HRC Journal of High Resolution Chromatography, 22 (3), 153-158
Document type
article