Title
Phyto-oestrogen excretion and rate of bone loss in postmenopausal women
Author
Kardinaal, A.F.M.
Morton, M.S.
Brüggemann-Rotgans, I.E.M.
van Beresteijn, E.C.H.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1998
Abstract
Objective: The hypothesis was tested that the rate of postmenopausal bone loss is inversely associated with long-term urinary excretion of phyto-oestrogens, as a marker of habitual dietary intake. Design: Secondary analysis of a 10-year follow-up study (1979-1989) among postmenopausal women in the Netherlands. Subjects: From the original population of 154 women, 32 women were selected with an annual rate of radial bone loss of ≤ 0.5% over the first 5 years of the study and 35 women with a rate of ≥ 2.5% per year. Methods: The isoflavonoids genistein, daidzein and equol, and the lignan enterolactone were determined by gas chromatography - mass spectrometry in aggregate samples from annually collected urine samples. Cortical bone density of the radius had previously been measured annually by single-photon absorptiometry. Results: Excretion of isoflavonoids did not differ between both groups, although in multivariate analysis equol excretion was weakly positively associated with rate of bone loss in the 5 years after the menopause. Enterolactone excretion was significantly higher in the group with high rate of bone loss. This positive association remained in multivariate linear regression analysis after adjustment for age, years since menopause, body mass index and intake of calcium, vegetable protein and dietary fibre. Conclusions: Enterolactone excretion is likely to be an indicator of consumption of grains and legumes; it is not clear whether the observed positive association with rate of bone loss is a causal one. Our results do not support a preventive effect of low, unsupplemented dietary intake of phyto-oestrogens on postmenopausal cortical bone loss. However, no conclusions can be drawn about effects of higher doses of phyto-oestrogens.
Subject
Nutrition
Bone density
Menopause
Oestrogens
Osteoporosis
Urinary isoflavones
Urinary lignans
Calcium
Daidzein
Enterolactone
Equol
Genistein
Isoflavone derivative
Lignan
Phytoestrogen
Vegetable protein
Adult
Age
Body mass
Bone atrophy
Bone density
Calcium intake
Clinical article
Cortical bone
Dietary fiber
Dietary intake
Female
Follow up
Gas chromatography
Human
Mass spectrometry
Postmenopause
Protein intake
Single photon emission computer tomography
Urinary excretion
4-Butyrolactone
Aging
Bone Density
Chromans
Estrogens, Non-Steroidal
Female
Gas Chromatography-Mass Spectrometry
Genistein
Humans
Isoflavones
Lignans
Linear Models
Middle Aged
Osteoporosis, Postmenopausal
Phytoestrogens
Plant Preparations
Postmenopause
Prospective Studies
Time Factors
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TNO identifier
86469
ISSN
0954-3007
Source
European Journal of Clinical Nutrition, 52 (11), 850-855
Document type
article