Print Email Facebook Twitter Cost-effectiveness of newborn screening for severe combined immunodeficiency Title Cost-effectiveness of newborn screening for severe combined immunodeficiency Author van der Ploeg, C.P.B. Blom, M. Bredius, R.G.M. van der Burg, M. Schielen, P.C.J.I. Verkerk, P.H. van den Akker-van Marle, M.E. Publication year 2019 Abstract Severe combined immunodeficiency (SCID) is a condition that often results in severe infections and death at young age. Early detection shortly after birth, followed by treatment before infections occur, largely increases the chances of survival. As the incidence of SCID is low, assessing cost-effectiveness of adding screening for SCID to the newborn screening program is relevant for decision making. Lifetime costs and effects of newborn screening for SCID were compared to a situation without screening in the Netherlands in a decision analysis model. Model parameters were based on literature and expert opinions. Sensitivity analyses were performed. Due to earlier detection, the number of deaths due to SCID per 100,000 children was assessed to decrease from 0.57 to 0.23 and a number of 11.7 quality adjusted life-years (QALYs) gained was expected. Total yearly healthcare costs, including costs of screening, diagnostics, and treatment, were €390,800 higher in a situation with screening compared to a situation without screening, resulting in a cost-utility ratio of €33,400 per QALY gained. Conclusion: Newborn screening for SCID might be cost-effective. However, there is still a lot of uncertainty around the cost-effectiveness estimate. Pilot screening projects are warranted to obtain more accurate estimates for the European situation. Subject LifeCH - Child HealthELSS - Earth, Life and Social SciencesHealthy for LifeHealthy LivingSevere combined immunodeficiency (SCID)Cost-effectiveness analysisNewborn screeningDecision analysis model To reference this document use: http://resolver.tudelft.nl/uuid:f85dee2b-7d6e-4691-a45f-a5b2e6efe99e DOI https://doi.org/10.1007/s00431-019-03346-3 TNO identifier 862239 Source European Journal of Pediatrics, 178 (5), 721-729 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.