Title
The 5T mouse multiple myeloma model: Absence of c-myc oncogene rearrangement in early transplant generations
Author
Instituut voor Experimentele Gerontologie TNO
Radl, J.
Punt, Y.A.
van den Enden-Vieveen, M.H.M.
Bentvelzen, P.A.J.
Bakkus, M.H.C.
van den Akker T., W.
Benner, R.
Publication year
1990
Abstract
Consistent chromosomal translocations involving the c-myc cellular oncogene and one of the three immunoglobulin loci are typical for human Burkitt's lymphoma, induced mouse plasmacytoma (MPC) and spontaneously arising rat immunocytoma (RIC). Another plasma cell malignancy, multiple myeloma (MM), arising spontaneously in the ageing C57BL/KaLwRij mice, was investigated in order to see whether the MM cells contain c-myc abnormalities of the MPC or RIC type. Rearrangement of the c-myc oncogene was found in the bone marrow cells only in 5T2 MM transplantation line in a mouse of the 24th generation and in none of the seven other MM of the 5T series which were of earlier generations. Since the mouse 5T MM resembles the human MM very closely, including the absence of consistent structural c-myc oncogene abnormalities, it can serve as a useful experimental model for studies on the aetiopathogenesis of this disease.
Subject
Animal cell
Animal model
Gene rearrangement
Mouse
Nonhuman
Oncogene c myc
Animal
Autoradiography
Bone Marrow
Chromosome Mapping
DNA, Neoplasm
Female
Gene Rearrangement
Male
Mice
Mice, Inbred C57BL
Multiple Myeloma
Neoplasm Transplantation
Oncogenes
Spleen
Support, Non-U.S. Gov't
To reference this document use:
http://resolver.tudelft.nl/uuid:f64db1da-fd35-43ca-bda7-479ae818d261
TNO identifier
231031
ISSN
0007-0920
Source
British Journal of Cancer, 61 (61), 276-278
Document type
article