Title
Dietary effects on coagulation factor VII vary across genotypes of the R/Q353 polymorphism in elderly people
Author
Mennen, L.I.
de Maat, M.P.M.
Schouten, E.G.
Kluft, C.
Witteman, J.C.M.
Hofman, A.
Grobbee, D.E.
Gaubius Instituut TNO
Publication year
1998
Abstract
The objective of this study was to evaluate the association of factor VII with dietary factors while also considering the R/Q353 polymorphism. Nutrition is an important determinant of coagulation factor VII, which is also genetically determined by the R/Q353 polymorphism. High levels of coagulation factor VII clotting activity (FVII:C) are associated with the risk of myocardial infarction; nutrition may have an effect on these levels if people are genetically susceptible to dietary changes. FVII:C was measured in 3005 elderly subjects, and the extreme quintiles of the FVII:C distribution were selected for measurement of the R/Q353 genotype and FVII:Chr (reflects total factor VII). In these 1158 subjects, habitual diet was assessed with a semiquantitative food-frequency questionnaire. The frequency of the Q353 allele was 0.24 in the lowest and 0.09 in the highest quintile. The quintiles were combined for linear regression analyses. FVII:C was inversely associated with fiber [β = -0.64 % pooled plasma (PP)/g, confidence interval (CI): -1.07,-0.21] and protein intake (β = -0.16 % PP/g, CI: -0.31,-0.01) and positively with saturated fat intake (β = 0.19 % PP/g, CI: -0.10,0.48). FVII:Chr was inversely associated with fiber (β = -0.38 % PP/g, CI: -0.71 ,-0.05). No other associations with diet were observed. The inverse association of FVII:C with fiber was stronger in subjects with the RR genotype (β = -0.76 % PP/g, CI: -1.23,-0.29), than in those with the RQ/QQ genotypes (β = -0.19 % PP/g, CI: -0.97,0.59). The same was found for FVII:Chr. The association of FVII:C with saturated fat was positive in those with the RR allele and inverse in those carrying the Q allele. These findings suggest that the strength of the association between coagulation factor VII and diet varies across the genotypes of the R/Q353 polymorphism.
Subject
Biology
Dietary fat
Dietary fiber
Elderly people
Factor VII
R/Q353 polymorphism
Aged
Cohort Studies
Confidence Intervals
Dietary Fats
Dietary Fiber
Dietary Proteins
Factor VII
Female
Genotype
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Prospective Studies
Regression Analysis
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TNO identifier
234450
ISSN
0022-3166
Source
Journal of Nutrition, 128 (5), 870-874
Document type
article