Print Email Facebook Twitter Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects Title Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects Author van Dokkum, W. Wezendonk, B. Srikumar, T.S. van den Heuvel, E.G.H.M. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1999 Abstract Objective: To study the effect of the intake of 15 g nondigestible oligosaccharides per day on various parameters of large-bowel function, as well as on blood lipid concentrations and glucose absorption in man. Design: Latin square, randomized, double-blind, diet-controlled. Setting: Metabolic research unit. Subjects: Twelve apparently healthy men (mean age 23 years), recruited from the Institute's pool of volunteers, no drop-outs. Interventions: Four treatment periods of 3 weeks: inulin, fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS) and control; analyses of stool weight, intestinal transit, faecal pH, short-chain fatty acids, bile acids, faecal enzymes, blood lipids and glucose absorption. Results: As compared to the control treatment: higher concentration of faecal acetate (inulin and GOS, P < 0.05) and valerate (inulin, P < 0.05), significantly lower concentration of faecal deoxycholic acid (inulin and FOS, P < 0.05 and P < 0.02, respectively) and β-glucuronidase activity (inulin and GOS, P < 0.05 and P < 0.02 respectively). Other changes of faecal parameters and those of blood lipids and glucose absorption were statistically not significant. Conclusions: Results indicate that nondigestible oligosaccharides are (partly) fermented in the human colon, but in healthy young men the effects are limited. Also the consumption of 15 g nondigestible oligosaccharides does not seem to alter blood lipid concentrations and glucose absorption in our young healthy adults. Subject NutritionBlood lipidsBowel functionFaecal parametersGlucose absorptionHumansOligosaccharidesAcetic acidBeta glucuronidaseBile acidDeoxycholic acidEnzymeFructose oligosaccharideGlucoseInulinLipidOligosaccharideShort chain fatty acidValeric acidAdultClinical trialControlled clinical trialControlled studyDouble blind procedureFeces analysisGlucose absorptionHumanHuman experimentIntestine functionLarge intestineLatin square designLipid blood levelMaleNormal humanPHRandomized controlled trialStatistical analysisBeta-GlucosidaseBlood Chemical AnalysisDietary FiberDouble-Blind MethodEatingFecesGlucoseGlucose Tolerance TestGlucuronidaseHumansIntestinal AbsorptionIntestine, LargeLipidsOligosaccharidesQuestionnairesTryptophanaseUrease To reference this document use: http://resolver.tudelft.nl/uuid:f5ab8033-1825-471a-a99a-14d062a99f1f TNO identifier 234921 ISSN 0954-3007 Source European Journal of Clinical Nutrition, 53 (1), 1-7 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.