Title
Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats
Author
de Jonge, J.D.
Ezendam, J.
Knippels, L.M.J.
Odink, J.
Pourier, M.S.
Penninks, A.H.
Pieters, R.
van Loveren, H.
TNO Kwaliteit van Leven
Publication year
2007
Abstract
Other factors than the allergen itself may be of importance in the development of food allergy. This report describes the influence of the immunosuppressive compound bis(tributyltin)oxide (TBTO), present in the food chain, on the development of food allergy to peanut or ovalbumin in Brown Norway (BN) rats. To study these effects BN rats were sensitized to either 1 or 10 mg peanut or ovalbumin by daily oral gavage and the TBTO-groups were fed a diet containing 80 mg TBTO per kg diet. Co-exposure to TBTO not only resulted in decreased general immunologic parameters such as weights of mesenteric lymph nodes and Peyer's patches, lymphocyte proliferation rates in splenocytes, but also on allergic parameters. In the peanut allergen-model TBTO decreased allergen-specific Th2 cytokine production by spleen cells, number of eosinophilic and basophilic granulocytes in the blood and production of mast cell protease II after oral food challenge. In the ovalbumin allergen-model TBTO decreased the number of eosinophilic and basophilic granulocytes, allergen-specific IgE and production of mast cell protease II after oral food challenge. The data imply that in the process of risk assessment of food allergy attention should be given to immunomodulating compounds present in the diet. © 2007 Elsevier Ireland Ltd. All rights reserved.
Subject
Health
Toxicology and Applied Pharmacology
Bis(tributyltin)oxide
Brown Norway rat
Food allergy
Ovalbumin
Peanut
TBTO
bis(tributyltin) oxide
cytokine
immunoglobulin E
ovalbumin
proteinase
animal cell
animal experiment
animal model
article
basophil
controlled study
cytokine production
eosinophil
female
food allergy
food chain
granulocyte
immunology
immunomodulation
lymphocyte proliferation
mast cell
mesentery lymph node
nonhuman
peanut allergy
Peyer patch
priority journal
rat
risk assessment
spleen cell
Th2 cell
Adjuvants, Immunologic
Administration, Oral
Allergens
Animals
Antibody Formation
Cell Count
Cell Proliferation
Disease Models, Animal
Female
Granulocytes
Immunosuppressive Agents
Lymph Nodes
Lymphocytes
Mast Cells
Metalloendopeptidases
Ovalbumin
Peanut Hypersensitivity
Peyer's Patches
Rats
Rats, Inbred BN
Spleen
Trialkyltin Compounds
Arachis hypogaea
Rattus
Rattus norvegicus
To reference this document use:
http://resolver.tudelft.nl/uuid:f5a64d14-9ad0-40a8-8a5e-de358ed40a84
DOI
https://doi.org/10.1016/j.tox.2007.06.090
TNO identifier
240193
ISSN
0300-483X
Source
Toxicology, 239 (1-2), 68-76
Document type
article